{"title":"Stress \u0026 Sleep","description":"\u003cp\u003eHerbal formulas crafted to help you unwind, manage stress, and support restful sleep naturally.\u003c\/p\u003e","products":[{"product_id":"adrenal-stress-relief","title":"Adrenal + = Stress Relief","description":"\u003cp\u003eAn adrenal support formula for individuals who are \"burned out,\" with fatigue, no energy, and lack of interest, drive and satisfaction\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cdiv id=\"h1\"\u003e\n\u003cdiv\u003e\n\u003cp\u003eAdrenal + \u003csup\u003e™\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection1\"\u003e\n\u003cp\u003eCLINICAL APPLICATIONS\u003c\/p\u003e\n\u003cp\u003e* Adrenal insufficiency or low adrenal functions\u003c\/p\u003e\n\u003cp\u003e* Premature aging\u003c\/p\u003e\n\u003cp\u003e* Diminished sexual and reproductive functions\u003c\/p\u003e\n\u003cp\u003e* Patients who are \"burned out,\" with fatigue, no energy, lack of interest, lack of drive and satisfaction\u003c\/p\u003e\n\u003cp\u003eWESTERN THERAPEUTIC ACTIONS\u003c\/p\u003e\n\u003cp\u003e* Regulates and improves the function of the adrenal glands and the endocrine system\u003c\/p\u003e\n\u003cp\u003e* Improves mental acuity and physical performance\u003c\/p\u003e\n\u003cp\u003e* Restores normal sexual and reproductive functions\u003c\/p\u003e\n\u003cp\u003e* Enhances the immune system\u003c\/p\u003e\n\u003cp\u003eCHINESE THERAPEUTIC ACTIONS\u003c\/p\u003e\n\u003cp\u003e* Tonifies Kidney yin, yang, and jing (essence)\u003c\/p\u003e\n\u003cp\u003e* Tonifies the qi and blood\u003c\/p\u003e\n\u003cp\u003e* Strengthens the Spleen and Stomach\u003c\/p\u003e\n\u003cp\u003eDOSAGE\u003c\/p\u003e\n\u003cp\u003eTake 3 to 4 capsules three times daily on an empty stomach with warm water. The dosage may be increased to 6 to 8 capsules three times daily, if necessary. For maintenance, take 1 to 2 capsules daily.\u003c\/p\u003e\n\u003cp\u003eINGREDIENTS\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection2\"\u003e\n\u003cp\u003eBa Ji Tian (Radix Morindae Officinalis)\u003c\/p\u003e\n\u003cp\u003eDa Zao (Fructus Jujubae)\u003c\/p\u003e\n\u003cp\u003eDu Zhong (Cortex Eucommiae)\u003c\/p\u003e\n\u003cp\u003eFu Ling (Poria)\u003c\/p\u003e\n\u003cp\u003eFu Zi (Radix Aconiti Lateralis Praeparata)\u003c\/p\u003e\n\u003cp\u003eGou Qi Zi (Fructus Lycii)\u003c\/p\u003e\n\u003cp\u003eMu Dan Pi (Cortex Moutan)\u003c\/p\u003e\n\u003cp\u003eNiu Xi (Radix Achyranthis Bidentatae)\u003c\/p\u003e\n\u003cp\u003eRen Shen (Radix et Rhizoma Ginseng)\u003c\/p\u003e\n\u003cp\u003eRou Gui (Cortex Cinnamomi)\u003c\/p\u003e\n\u003cp\u003eShan Yao (Rhizoma Dioscoreae)\u003c\/p\u003e\n\u003cp\u003eShan Zhu Yu (Fructus Corni)\u003c\/p\u003e\n\u003cp\u003eShi Chang Pu (Rhizoma Acori Tatarinowii)\u003c\/p\u003e\n\u003cp\u003eShu Di Huang (Radix Rehmanniae Praeparata)\u003c\/p\u003e\n\u003cp\u003eSuo Yang (Herba Cynomorii)\u003c\/p\u003e\n\u003cp\u003eWu Wei Zi (Fructus Schisandrae Chinensis)\u003c\/p\u003e\n\u003cp\u003eXiao Hui Xiang (Fructus Foeniculi)\u003c\/p\u003e\n\u003cp\u003eYuan Zhi (Radix Polygalae)\u003c\/p\u003e\n\u003cp\u003eZe Xie (Rhizoma Alismatis)\u003c\/p\u003e\n\u003cp\u003eZhi Gan Cao (Radix et Rhizoma Glycyrrhizae Praeparata cum Melle)\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection3\"\u003e\n\u003cp\u003eBACKGROUND\u003c\/p\u003e\n\u003cp\u003eThe adrenal glands, two triangular glands on top of the kidneys, are responsible for the production and release of cortisol in response to stress. If an individual suffers from chronic stress or manages stress poorly, the function of the adrenal glands will be affected, resulting in adrenal insufficiency or adrenal fatigue. Clinical manifestations including anxiety, depression, fatigue, intolerance for stress, increased allergy and sensitivity to foods and chemicals, and a tendency to feel cold.\u003c\/p\u003e\n\u003cp\u003eFORMULA EXPLANATION\u003c\/p\u003e\n\u003cp\u003eAdrenal + is designed to treat patients who are \"burned out,\" with symptoms of premature aging, fatigue, no energy, lack of interest, drive, and satisfaction. Such conditions may be caused by excessive stress, anxiety, tension, overwork, and lack of rest. From the traditional Chinese medicine perspective, there is an excessive consumption of qi, blood, yin, yang, and Kidney jing (essence), accompanied by deficiency of Spleen, Stomach, Heart and Kidney. Deficiency of the Spleen and Stomach leads to an inadequate supply of qi, shown by symptoms of generalized weakness, fatigue, and anorexia. Deficiency of Heart qi and blood may contribute to forgetfulness, being easily frightened, low-grade fever, and night sweats. Deficiency of yin and yang leads to premature aging. Lastly, the lack of jing (essence) contributes further to Kidney deficiency, leading to decreased libido, spermatorrhea, and other sexual disorders.\u003c\/p\u003e\n\u003cp\u003eIn this formula, a large portion of Ren Shen (Radix et Rhizoma Ginseng) is used because it is the most effective and potent herb to tonify qi, strengthen the Lung and the Spleen, and improve mental functioning. It has excellent adaptogenic functions to help the body adjust to various stressful situations. Studies have shown that Ren Shen (Radix et Rhizoma Ginseng) improves both mental and physical functions.\u003c\/p\u003e\n\u003cp\u003eIn addition, Suo Yang (Herba Cynomorii), Ba Ji Tian (Radix Morindae Officinalis), and Xiao Hui Xiang (Fructus Foeniculi) strengthen the Spleen and the Kidney. Shu Di Huang (Radix Rehmanniae Praeparata) and Gou Qi Zi (Fructus Lycii) nourish the Kidney and benefit qi. Du Zhong (Cortex Eucommiae) and Niu Xi (Radix Achyranthis Bidentatae) tonify the Kidney and strengthen the knees and the lower back. Fu Ling (Poria) and Shan Yao (Rhizoma Dioscoreae) strengthen the Spleen and dissolve dampness. Shan Yao (Rhizoma Dioscoreae) and Wu Wei Zi (Fructus Schisandrae Chinensis) tonify the Lung and prevent leakage of Lung qi. Furthermore, they reduce the loss of fluids from the Kidney, particularly via spermatorrhea. Yuan Zhi (Radix Polygalae) tonifies the Heart and calms the shen (spirit). Shi Chang Pu (Rhizoma Acori Tatarinowii) opens the sensory orifices, improves mental functioning, and increases alertness. Da Zao (Fructus Jujubae) tonifies both qi and blood, and strengthens the Lung and Spleen functions.\u003c\/p\u003e\n\u003cp\u003eFurthermore, Ze Xie (Rhizoma Alismatis) settles turbidity in the Kidney and controls the potential stagnation that may be associated with the use of Shu Di Huang (Radix Rehmanniae Praeparata). Mu Dan Pi (Cortex Moutan) sedates deficiency fire of the Liver; it also balances the astringent property of Shan Zhu Yu (Fructus Corni). Fu Ling (Poria), as a sedating herb used with Shan Yao (Rhizoma Dioscoreae), dispels damp through urination and tonifies the middle jiao.\u003c\/p\u003e\n\u003cp\u003eHot in nature, Fu Zi (Radix Aconiti Lateralis Praeparata) and Rou Gui (Cortex Cinnamomi) revitalize Kidney yang and warm the lower body. Fu Zi (Radix Aconiti Lateralis Praeparata) is excellent for treatment of various chronic cold-type disorders associated with the endocrine, cardiovascular and musculoskeletal systems. Rou Gui (Cortex Cinnamomi) strengthens the Spleen and tonifies Kidney yang.\u003c\/p\u003e\n\u003cp\u003eLastly, Zhi Gan Cao (Radix et Rhizoma Glycyrrhizae Praeparata cum Melle) tonifies qi and harmonizes the actions of the other herbs.\u003c\/p\u003e\n\u003cp\u003eCAUTIONS \u0026amp; CONTRAINDICATIONS\u003c\/p\u003e\n\u003cp\u003e* This formula is contraindicated during pregnancy and nursing.\u003c\/p\u003e\n\u003cp\u003e* This formula is not recommended in cases with exterior or excess conditions. It should not be used in cases of infections and inflammations.\u003c\/p\u003e\n\u003cp\u003e* This formula should be used with caution in patients with yin deficiency, since this formula is warm in nature.\u003c\/p\u003e\n\u003cp\u003e* This formula may be taken with a small amount of salt as a channel-guiding substance to enhance the Kidney-tonic properties.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePatients who wear a pacemaker, or individuals who take antiarrhythmic drugs or cardiac glycosides such as Lanoxin (digoxin), should not take this formula. Fu Zi (Radix Aconiti Lateralis Praeparata) may interact with these drugs by affecting the rhythm and potentiating the contractile strength of the heart.[1]\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eSUPPLEMENTARY FORMULAS\u003c\/p\u003e\n\u003cp\u003e* For an immediate boost of energy, use with Vibrant.\u003c\/p\u003e\n\u003cp\u003e* For long-term restoration of vitality, use with Imperial Tonic.\u003c\/p\u003e\n\u003cp\u003e* For patients with hypothyroidism, use with Thyro-forte.\u003c\/p\u003e\n\u003cp\u003e* For sexual and reproductive disorders, use with Vitality.\u003c\/p\u003e\n\u003cp\u003e* For compromised immune system, use with Immune +.\u003c\/p\u003e\n\u003cp\u003e* For stomach and duodenal ulcers, use with GI Care.\u003c\/p\u003e\n\u003cp\u003e* For stress and anxiety, use with Calm.\u003c\/p\u003e\n\u003cp\u003e* For severe stress and anxiety, use with Calm (ES).\u003c\/p\u003e\n\u003cp\u003e* For stress, anxiety, and insomnia, use with Calm ZZZ.\u003c\/p\u003e\n\u003cp\u003e* For insomnia, use with Schisandra ZZZ.\u003c\/p\u003e\n\u003cp\u003e* For obesity, use with Herbalite.\u003c\/p\u003e\n\u003cp\u003e* For weakness and deficiency of the Lung, use with Cordyceps 3.\u003c\/p\u003e\n\u003cp\u003e* For poor memory, use with Enhance Memory.\u003c\/p\u003e\n\u003cp\u003e* For general Kidney yang deficiency, add Kidney Tonic (Yang).\u003c\/p\u003e\n\u003cp\u003e* For general Kidney yin deficiency, add Kidney Tonic (Yin).\u003c\/p\u003e\n\u003cp\u003eFor male infertility, add Vital Essence.\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cdiv id=\"h1\"\u003e\n\u003cdiv class=\"WordSection3\"\u003e\n\u003cp\u003eNUTRITION\u003c\/p\u003e\n\u003cp\u003e* Increase the consumption of fresh fruits, vegetables, grains, seeds, and nuts.\u003c\/p\u003e\n\u003cp\u003e* Eat more fish and fish oils, onions, garlic, olives, olive oil, herbs, spices, yogurt, fiber, and tofu or other soy products.\u003c\/p\u003e\n\u003cp\u003e* Sea vegetables, such as kelp and dulse, replenish the body with minerals like magnesium, potassium, calcium, iodine, and iron.\u003c\/p\u003e\n\u003cp\u003e* Ensure adequate intake of vitamin B complex to process and utilize energy.\u003c\/p\u003e\n\u003cp\u003e* Decrease intake of alcohol, fats, and highly processed foods.\u003c\/p\u003e\n\u003cp\u003e* Avoid the use of stimulants, such as coffee, caffeine, and high-sugar products.\u003c\/p\u003e\n\u003cp\u003e* Food allergies or chemical hypersensitivity can drain energy and cause fatigue. Additional tests are necessary to rule out allergy and\/or hypersensitivity.\u003c\/p\u003e\n\u003cp\u003eThe Tao of Nutrition by Dr. Maoshing Ni and Cathy McNease:\u003c\/p\u003e\n\u003cp\u003e* Kidney yang deficiency: Consume warming foods such as chicken, lamb, scallions, sesame seeds, fish, baked tofu, soybeans, walnuts, eggs, lentils, black beans, lotus seeds, a little wine, ginger, cinnamon bark tea.\u003c\/p\u003e\n\u003cp\u003e* Kidney yin deficiency: Consume cooling foods such as mulberries, apples, peaches, pears, fresh vegetables, mung beans, soybeans, tofu, soy sprouts, chrysanthemum flowers.\u003c\/p\u003e\n\u003cp\u003eLIFESTYLE INSTRUCTIONS\u003c\/p\u003e\n\u003cp\u003e* Get regular exercise and adequate rest.\u003c\/p\u003e\n\u003cp\u003e* For relaxation and better sleep, take a warm bath for about 20 minutes before bedtime. Sea salt or Epsom salt can also be added.\u003c\/p\u003e\n\u003cp\u003e* Engage in activities such as tai chi chuan [tai ji chuan], walking, or meditation that allow calming of the mind without creating stagnation or excessive fatigue.\u003c\/p\u003e\n\u003cp\u003e* Avoid exposure to heavy metals such as lead, cadmium, aluminum, copper, and arsenic, all of which can suppress the immune system and cause fatigue. Those who have already been exposed should take Herbal DTX to eliminate these toxins.\u003c\/p\u003e\n\u003ch3\u003e\u003cspan style=\"font-size: 14px; font-weight: 400;\"\u003eCASE STUDIES\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e* M.H., a 66-year-old female patient, presented with tiredness, weakness, inability to exercise with desire to rest frequently, and some anxiety. Her blood pressure was 145\/70 mmHg and her heart rate was 88 beats per minute. Laboratory results showed K 5 mmol\/L, Na 140 mmol\/L, Cl 103 mmol\/L, CO2 26 mmol\/L, and Anion gap 15.8 mmol\/L. According to the results, high potassium signified adrenal stress, and high anion gap showed dysglycemia. The practitioner diagnosed this condition as Kidney qi deficiency with yin and yang deficiencies. Other objective findings were cold hands and feet. Adrenal + was prescribed at three capsules three times daily and as needed after exercising. The results were good. The patient reported that she was satisfied with the herbs and noticed the difference in energy it had given her. Submitted by N.H., Chatsworth, California.\u003c\/p\u003e\n\u003cp\u003e* L.D., a 31-year-old female, presented with fatigue, dizziness, low body temperature, coldness, and muscle weakness. Her blood pressure was 100\/60 mmHg and her heart rate was 65 beats per minute. Her Western diagnosis was hypotension and hypoglycemia. Laboratory result showed she had decreased thyroid activity and adrenal medullary insufficiency. The diagnosis was yang deficiency. She was prescribed Thyro-forte and Adrenal + at 2.5 and 1.5 grams per day, respectively. She did not receive any acupuncture. After two months, she felt much more energized and the dizziness was gone. She no longer felt cold. Submitted by W.F., Bloomfield, New Jersey.\u003c\/p\u003e\n\u003cp\u003ePHARMACOLOGICAL AND CLINICAL RESEARCH\u003c\/p\u003e\n\u003cp\u003eAdrenal + is designed to treat patients who are \"burned out,\" with fatigue and lethargy accompanied by premature aging and a decline in mental acuity and physical performance. It contains herbs that stimulate the mind, improve physical strength, restore sexual prowess, and enhance the immune system.\u003c\/p\u003e\n\u003cp\u003eThe endocrine system has a significant impact on the regulation of various glands in the body, including, but not limited to, the hypothalamus, pituitary, thyroid, parathyroid, the adrenal glands, gonads, pancreas, and paraganglia.[2] The imbalance of the endocrine system will affect the glands, and disorder of the glands will also affect the endocrine system. To properly address such conditions, this formula uses many herbs to regulate and restore the endocrine system and the glands. For example, Shu Di Huang (Radix Rehmanniae Praeparata) has been shown to increase plasma levels of adrenal cortical hormone.[3] Ba Ji Tian (Radix Morindae Officinalis) has a stimulating effect on the pituitary gland and the adrenal cortex, and its administration has been associated with an increase in plasma levels of corticosteroids.[4] Administration of glycyrrhizin and glycyrrhetinic, two active ingredients in Zhi Gan Cao (Radix et Rhizoma Glycyrrhizae Praeparata cum Melle), clearly enhances the overall duration and influence of cortisone as demonstrated by various laboratory studies.[5] One clinical trial showed that patients with declining pituitary gland function were successfully treated by continuous use of Ren Shen (Radix et Rhizoma Ginseng) and Zhi Gan Cao (Radix et Rhizoma Glycyrrhizae Praeparata cum Melle) for two to three months.[6] Since the long-term use of Zhi Gan Cao (Radix et Rhizoma Glycyrrhizae Praeparata cum Melle) is sometimes associated with cellular accumulation of water, Ze Xie (Rhizoma Alismatis) is added for its diuretic action to alleviate this potential side effect.[7] Other herbs that affect and improve the endocrine system include Shan Zhu Yu (Fructus Corni), Du Zhong (Cortex Eucommiae), and Ba Ji Tian (Radix Morindae Officinalis).[8,9]\u003c\/p\u003e\n\u003cp\u003eIn addition to regulating the endocrine system, it is also important to restore optimal mental and physical functioning. Shi Chang Pu (Rhizoma Acori Tatarinowii) and Ren Shen (Radix et Rhizoma Ginseng) improve mental acuity. In laboratory studies, administration of Shi Chang Pu (Rhizoma Acori Tatarinowii) is associated with improvement of memory.[10] In clinical studies, use of Ren Shen (Radix et Rhizoma Ginseng) is associated with marked effectiveness in improving memory and learning ability.[11] In one study on mental retardation, 30 children with low IQ took a formula comprised of Ren Shen (Radix et Rhizoma Ginseng) and three other herbs and showed mild to moderate improvement in classroom performance.[12] Furthermore, Da Zao (Fructus Jujubae) and Ba Ji Tian (Radix Morindae Officinalis) improve physical performance. In comparison with placebo substances, both of these herbs showed significant capacity to increase body weight, muscle strength, and physical endurance.[13,14]\u003c\/p\u003e\n\u003cp\u003eFurthermore, many herbs in this formula function to improve sexual and reproductive functions. Use of Gou Qi Zi (Fructus Lycii) is highly effective to improve low sperm count and poor motility.[15] Wu Wei Zi (Fructus Schisandrae Chinensis) has a stimulating effect on reproductive organs, increasing the weight of the testicles in males and inducing ovulation in females.[16] In another study, patients with impotence were treated with Ren Shen (Radix et Rhizoma Ginseng) with marked success. Out of 27 patients, 15 regained normal function, 9 had moderate improvement, and 3 showed no effect. Lastly, in one clinical study, 24 patients with low sperm count, treated with a preparation of Ren Shen (Radix et Rhizoma Ginseng), demonstrated an increase in sperm count in 70% of the patients, and an increase in sperm motility in 67% of the patients.[17]\u003c\/p\u003e\n\u003cp\u003eSince patients who are weak and deficient often have a suppressed immune system, herbs are included in this formula to strengthen the body and enhance the immune system. According to studies, use of a Rou Gui (Cortex Cinnamomi) preparation for five days increased white blood cell count by 150 to 200%, and use of Ren Shen (Radix et Rhizoma Ginseng) increased the total count of IgM.[18,19] Additionally, Gou Qi Zi (Fructus Lycii) and Du Zhong (Cortex Eucommiae) increase non-specific immunity, as they promote phagocytic activity by the macrophages, and increase the total number of T cells.[20,21,22]\u003c\/p\u003e\n\u003cp\u003eIn summary, Adrenal + contains herbs that have excellent effects of regulating the adrenal glands and balancing the endocrine system. It is a key formula to treat patients experiencing premature aging, declining mental and physical functioning, or who are simply \"burned out\" with fatigue, no energy, lack of interest, lack of drive and satisfaction.\u003c\/p\u003e\n\u003ch3\u003e\u003cspan style=\"font-size: 14px; font-weight: 400;\"\u003eCOMPARATIVE ANALYSIS\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003eAdrenal insufficiency or low adrenal functions are general terms used here to describe individuals who have premature aging or are \"burned out,\" with fatigue, no energy, lack of interest, lack of drive and satisfaction. These conditions affect overall health, and often lead to diminished mental and physical functions.\u003c\/p\u003e\n\u003cp\u003eAdrenal insufficiency technically and specifically refers to conditions such as Addison's disease. Such serious conditions are often treated with various types of intravenous or oral adrenocortical hormones. Though effective, they often have a great number of side effects, including immune suppression, increased frequency of and decreased resistance to infections, decreased or blurred vision, filling or rounding out of the face, frequent urination, increased thirst, abdominal or stomach pain, acne, bloody or black (tarry) stools, headache, irregular heartbeat, menstrual problems, muscle cramps or pain, muscle weakness, nausea, pain throughout the body, sensitivity of eyes to light, stunting of growth (in children), swelling of feet or lower legs, tearing of eyes, thin and shiny skin, difficulty sleeping, unusual bruising, unusual increase in hair growth, unusual tiredness or weakness, rapid weight gain, and non-healing wounds. Therefore, unless the patients are diagnosed with the biomedical condition of adrenal cortical hypofunction, potent drugs such as adrenocortical hormones are not used.\u003c\/p\u003e\n\u003cp\u003eAdrenal insufficiency is used to describe the general signs and symptoms of qi, blood, yin, yang, and Kidney jing (essence) depletion accompanied by Spleen, Stomach, Heart and Kidney deficiencies. As described above, Adrenal + has excellent functions to regulate the endocrine system, stimulate the adrenal glands, and improve mental and physical functions. Though herbs do not treat specific and serious conditions such as Addison's disease, they do offer excellent preventative and treatment effects for individuals who are \"burned out,\" with fatigue, no energy, lack of interest, lack of drive and satisfaction. Most importantly, herbal therapy has a significantly better safety profile in comparison with drug treatments.\u003c\/p\u003e\n\u003cp\u003e[1] Forensic Science International, 1994 June 28; 55-8.\u003c\/p\u003e\n\u003cp\u003e[2] Dorland’s Illustrated Medical Dictionary, 28th Edition. W.B.Saunders Company, 1994.\u003c\/p\u003e\n\u003cp\u003e[3] Zhong Yao Xue (Chinese Herbology), 1998; 156:158.\u003c\/p\u003e\n\u003cp\u003e[4] Guo Wai Yi Xue Zhong Yi Zhong Yao Fen Ce (Monograph of Chinese Herbology from Foreign Medicine), 1990; 12(6):48.\u003c\/p\u003e\n\u003cp\u003e[5] Zhong Yao Zhi (Chinese Herbology Journal), 1993; 358.\u003c\/p\u003e\n\u003cp\u003e[6] Zhong Hua Yi Xue Za Zhi (Chinese Journal of Medicine), 1975; 10:718.\u003c\/p\u003e\n\u003cp\u003e[7] Sheng Yao Xue Za Zhi (Journal of Raw Herbology), 1982; 36(2):150.\u003c\/p\u003e\n\u003cp\u003e[8] Zhong Yao Yao Li Yu Lin Chuang (Pharmacology and Clinical Applications of Chinese Herbs), 1989; 5(1):36.\u003c\/p\u003e\n\u003cp\u003e[9] Zhong Yi Xue (Chinese Herbal Medicine), 1982; 13(6):24.\u003c\/p\u003e\n\u003cp\u003e[10] Zhong Yi Xue (Chinese Herbal Medicine), 1992; 23(8):417.\u003c\/p\u003e\n\u003cp\u003e[11] Zhong Yao Ci Hai (Encyclopedia of Chinese Herbs), 1994.\u003c\/p\u003e\n\u003cp\u003e[12] Zhong Cheng Yao Yan Jiu (Research of Chinese Patent Medicine), 1982; 6:22.\u003c\/p\u003e\n\u003cp\u003e[13] Guo Wai Yi Xue Zhong Yi Zhong Yao Fen Ce (Monograph of Chinese Herbology from Foreign Medicine), 1985; 7(4):48.\u003c\/p\u003e\n\u003cp\u003e[14] Zhong Xi Yi Jie He Za Zhi (Journal of Integrated Chinese and Western Medicine), 1991; 11(7):415.\u003c\/p\u003e\n\u003cp\u003e[15] Xin Zhong Yi (New Chinese Medicine), 1988; 2:20.\u003c\/p\u003e\n\u003cp\u003e[16] Shang Hai Zhong Yi Yao Za Zhi (Shanghai Journal of Chinese Medicine and Herbology), 1989; 2:43.\u003c\/p\u003e\n\u003cp\u003e[17] Ji Lin Yi Xue (Jilin Medicine), 1983; 5:54.\u003c\/p\u003e\n\u003cp\u003e[18] Zhong Yao Yao Li Yu Ying Yong (Pharmacology and Applications of Chinese Herbs), 1983;443.\u003c\/p\u003e\n\u003cp\u003e[19] Zhong Yao Xue (Chinese Herbology), 1998; 729:736.\u003c\/p\u003e\n\u003cp\u003e[20] Zhong Yi Xue (Chinese Herbal Medicine), 1983;19(7):25.\u003c\/p\u003e\n\u003cp\u003e[21] Zhong Yi Xue (Chinese Herbal Medicine), 1983;14(8):27.\u003c\/p\u003e\n\u003cp\u003e[22] Zhong Xi Yi Jie He Za Zhi (Journal of Integrated Chinese and Western Medicine), 1988; 8(12):736.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd width=\"10%\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Modern Herbal Formulas","offers":[{"title":"Default Title","offer_id":53128928067695,"sku":null,"price":30.22,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0726\/8630\/5391\/files\/AD.jpg?v=1779233073"},{"product_id":"calm-es-extra-strength-stress-and-anxiety-remedy","title":"Calm (ES) = Extra Strength Stress and Anxiety Remedy","description":"\u003cp\u003eExtra-strength formula for severe restlessness, stress, and anxiety; also a support formula for craving and withdrawal associated with addiction\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cdiv id=\"h1\"\u003e\n\u003cdiv\u003e\n\u003cp\u003eCalm (ES) \u003csup\u003e™\u003c\/sup\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cdiv class=\"WordSection1\"\u003e\n\u003cp\u003eCLINICAL APPLICATIONS\u003c\/p\u003e\n\u003cp\u003e* Stress with poor appetite, headache, tension, insomnia, and similar stress responses\u003c\/p\u003e\n\u003cp\u003e* Extreme or severe emotional and psychological disorders, such as hysteria, neurosis, and schizophrenia\u003c\/p\u003e\n\u003cp\u003e* Insomnia with disturbed sleep and night awakenings\u003c\/p\u003e\n\u003cp\u003e* Withdrawal signs and symptoms associated with alcohol, drug, and smoking addiction\u003c\/p\u003e\n\u003cp\u003eWESTERN THERAPEUTIC ACTIONS\u003c\/p\u003e\n\u003cp\u003e* Sedative effect to relieve nervousness and irritability\u003c\/p\u003e\n\u003cp\u003e* Anxiolytic function to relieve stress and anxiety\u003c\/p\u003e\n\u003cp\u003e* Tranquilizing effect to alleviate severe emotional and psychological disorders\u003c\/p\u003e\n\u003cp\u003e* Antispasmodic effect to relieve muscle tension and cramping\u003c\/p\u003e\n\u003cp\u003e* Calming effect to ease withdrawal signs and symptoms associated with alcohol, drug, and smoking addiction\u003c\/p\u003e\n\u003cp\u003eCHINESE THERAPEUTIC ACTIONS\u003c\/p\u003e\n\u003cp\u003e* Spreads Liver qi, purges excess Liver fire\u003c\/p\u003e\n\u003cp\u003e* Calms the shen (spirit) and tranquilizes the Heart\u003c\/p\u003e\n\u003cp\u003eDOSAGE\u003c\/p\u003e\n\u003cp\u003eFor stress- and anxiety-related disorders, take 3 to 4 capsules three times daily. For severe emotional and psychological disorders, or patients with withdrawal signs and symptoms because of drug or alcohol addiction, the dosage may be increased to 6 to 8 capsules every four to six hours or as needed. Dosage can then be dropped down to 3 to 4 capsules three times daily when symptoms are stabilized.\u003c\/p\u003e\n\u003cp\u003eINGREDIENTS\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection2\"\u003e\n\u003cp\u003eBai Zhu (Rhizoma Atractylodis Macrocephalae)\u003c\/p\u003e\n\u003cp\u003eChai Hu (Radix Bupleuri)\u003c\/p\u003e\n\u003cp\u003eChuan Xiong (Rhizoma Chuanxiong)\u003c\/p\u003e\n\u003cp\u003eDa Huang (Radix et Rhizoma Rhei)\u003c\/p\u003e\n\u003cp\u003eDa Zao (Fructus Jujubae)\u003c\/p\u003e\n\u003cp\u003eDang Gui (Radix Angelicae Sinensis)\u003c\/p\u003e\n\u003cp\u003eFu Ling (Poria)\u003c\/p\u003e\n\u003cp\u003eGan Cao (Radix et Rhizoma Glycyrrhizae)\u003c\/p\u003e\n\u003cp\u003eGou Teng (Ramulus Uncariae cum Uncis)\u003c\/p\u003e\n\u003cp\u003eGui Zhi (Ramulus Cinnamomi)\u003c\/p\u003e\n\u003cp\u003eHuang Qin (Radix Scutellariae)\u003c\/p\u003e\n\u003cp\u003eLong Gu (Os Draconis)\u003c\/p\u003e\n\u003cp\u003eMu Li (Concha Ostreae)\u003c\/p\u003e\n\u003cp\u003eSheng Jiang (Rhizoma Zingiberis Recens)\u003c\/p\u003e\n\u003cp\u003eSuan Zao Ren (Semen Ziziphi Spinosae)\u003c\/p\u003e\n\u003cp\u003eXi Yang Shen (Radix Panacis Quinquefolii)\u003c\/p\u003e\n\u003cp\u003eXie Cao (Radix et Rhizoma Valerianae)\u003c\/p\u003e\n\u003cp\u003eZhu Ru (Caulis Bambusae in Taenia)\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection3\"\u003e\n\u003cp\u003eBACKGROUND\u003c\/p\u003e\n\u003cp\u003eStress is a normal physical and psychological reaction to demands of life. Most people experience challenges with mental or physical stress on a regular basis. When confronted with stress, the body responds with a burst of hormones to empower the organism to cope and survive – a reaction that is labeled as the \"fight-or-flight\" response. Once the stress is gone, however, the body is supposed to return to a normal relaxed state. Unfortunately, the nonstop stress of modern life often keeps the body in a constantly stressed state. Over time, constantly living in a stressed state coupled with an absence of relaxed states leads to serious health problems.\u003c\/p\u003e\n\u003cp\u003eFORMULA EXPLANATION\u003c\/p\u003e\n\u003cp\u003eCalm (ES) is one of the strongest herbal formulas to treat emotional and psychological disorders. In addition to regulating Liver qi and purging Liver fire, it also calms the shen (spirit) and tranquilizes the Heart. Clinically, it is commonly used for patients with severe emotional distress or mild psychological disorders. Furthermore, it can also be used to treat withdrawal signs and symptoms commonly associated with substance addiction.\u003c\/p\u003e\n\u003cp\u003eLong Gu (Os Draconis) and Mu Li (Concha Ostreae) are mineral medicinal substances commonly used to anchor the floating shen (spirit). They have tranquilizing and sedative effects, which can subdue the hyperactivity of Liver fire. Gou Teng (Ramulus Uncariae cum Uncis) treats headache associated with a sudden rise of blood pressure. Huang Qin (Radix Scutellariae) and Da Huang (Radix et Rhizoma Rhei) clear heat and relieve irritability. Chai Hu (Radix Bupleuri) disperses stagnant Liver qi and Dang Gui (Radix Angelicae Sinensis) nourishes Liver blood. Xi Yang Shen (Radix Panacis Quinquefolii), Bai Zhu (Rhizoma Atractylodis Macrocephalae), Fu Ling (Poria), Sheng Jiang (Rhizoma Zingiberis Recens), and Da Zao (Fructus Jujubae) strengthen and harmonize the middle jiao and prevent the Liver from overacting on the Spleen. Gui Zhi (Ramulus Cinnamomi) and Chuan Xiong (Rhizoma Chuanxiong) promote qi and blood circulation. Suan Zao Ren (Semen Ziziphi Spinosae) and Xie Cao (Radix et Rhizoma Valerianae) calm the Heart and nourish the shen (spirit). Gan Cao (Radix et Rhizoma Glycyrrhizae) harmonizes all the herbs in the formula and protects the stomach against the harshness of the mineral medicinal substances in this formula.\u003c\/p\u003e\n\u003cp\u003eCAUTIONS \u0026amp; CONTRAINDICATIONS\u003c\/p\u003e\n\u003cp\u003e* This formula is contraindicated during pregnancy and nursing.\u003c\/p\u003e\n\u003cp\u003e* Patients with a weak digestive system may experience mild gastrointestinal disturbances. In such cases, reduce the dosage or take this formula with GI Care for nausea, and Gentle Lax (Deficient) for constipation.\u003c\/p\u003e\n\u003cp\u003e* This herbal formula contains herbs that invigorate blood circulation, such as Dang Gui (Radix Angelicae Sinensis). Therefore, patients who are on anticoagulant or antiplatelet therapies, such as Coumadin (warfarin), should use this formula with caution, or not at all, as there may be a higher risk of bleeding and bruising.[1,2,3]\u003c\/p\u003e\n\u003cp\u003e* The following warning statement is required by the State of California: \"This product contains Da Huang (Radix et Rhizoma Rhei). Read and follow directions carefully. Do not use if you have or develop diarrhea, loose stools, or abdominal pain because Da Huang (Radix et Rhizoma Rhei) may worsen these conditions and be harmful to your health. Consult your physician if you have frequent diarrhea or if you are pregnant, nursing, taking medication, or have a medical condition.\"\u003c\/p\u003e\n\u003cp\u003eCLINICAL NOTES\u003c\/p\u003e\n\u003cp\u003e* In addition to using Calm (ES), efforts should be made to identify the underlying cause of illness. Both the symptoms and the cause should be treated concurrently to ensure optimal results.\u003c\/p\u003e\n\u003cp\u003eSUPPLEMENTARY FORMULAS\u003c\/p\u003e\n\u003cp\u003e* For moderate amounts of stress and anxiety or PMS, use Calm.\u003c\/p\u003e\n\u003cp\u003e* For stress and anxiety with insomnia in deficiency patients, use Calm ZZZ.\u003c\/p\u003e\n\u003cp\u003e* For insomnia arising from blood deficiency, add Schisandra ZZZ.\u003c\/p\u003e\n\u003cp\u003e* For crying spells or depression, add Shine or Shine (DS).\u003c\/p\u003e\n\u003cp\u003e* For ADD\/ADHD, add Calm (Jr).\u003c\/p\u003e\n\u003cp\u003e* For stress-related irritable bowel syndrome (IBS), add GI Harmony.\u003c\/p\u003e\n\u003cp\u003e* For stress-related ulcerative colitis, add GI Care (UC).\u003c\/p\u003e\n\u003cp\u003e* For chronic, stubborn insomnia with blood stagnation, add Circulation (SJ).\u003c\/p\u003e\n\u003cp\u003e* For menopausal signs, add Balance (Heat).\u003c\/p\u003e\n\u003cp\u003e* For hypertension, add Gentiana Complex or Gastrodia Complex.\u003c\/p\u003e\n\u003cp\u003e* For headache, add Corydalin (AC) or Corydalin (CR).\u003c\/p\u003e\n\u003cp\u003e* For constipation, combine with Gentle Lax (Excess) or Gentle Lax (Deficient).\u003c\/p\u003e\n\u003cp\u003e* If the patient has hyperthyroidism, add Thyrodex.\u003c\/p\u003e\n\u003cp\u003e* For heartburn or gastric ulcers, add GI Care.\u003c\/p\u003e\n\u003cp\u003e* For excess fire in the body, add Gardenia Complex.\u003c\/p\u003e\n\u003cp\u003e* For thirst and dryness, add Nourish (Fluids).\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cdiv id=\"h1\"\u003e\n\u003cdiv\u003e\n\u003cdiv class=\"WordSection3\"\u003e\n\u003cp\u003eNUTRITION\u003c\/p\u003e\n\u003cp\u003e* A diet high in calcium, magnesium, phosphorus, potassium, and vitamins B and E is recommended. These vitamins and minerals are easily depleted by stress.\u003c\/p\u003e\n\u003cp\u003e* Encourage the consumption of fruits and vegetables such as apricots, asparagus, avocados, bananas and broccoli. Brown rice, dried fruit, figs, salmon, garlic, green leafy vegetables, soy products, and yogurt are also recommended.\u003c\/p\u003e\n\u003cp\u003e* Avoid caffeine (coffee, tea, cola, chocolate), tobacco, alcohol and sugar whenever possible.[4]\u003c\/p\u003e\n\u003cp\u003e* Warm and hot natured foods that damage qi and yin should be avoided, such as:\u003c\/p\u003e\n\u003cp\u003e§ certain fruits like mango and durian that produce heat.\u003c\/p\u003e\n\u003cp\u003e§ stimulants like coffee, alcohol, and energy drinks.\u003c\/p\u003e\n\u003cp\u003e§ spicy\/pungent\/aromatic vegetables such as pepper, garlic, onions, basil, rosemary, cumin, funnel, anise, leeks, chives, scallions, thyme, saffron, wormwood, mustard, chili pepper, and wasabi.\u003c\/p\u003e\n\u003cp\u003e* Avoid food and drinks with artificial coloring.\u003c\/p\u003e\n\u003cp\u003e* Consume as few meat products as possible. Do not eat processed meats, such as lunch meats, hot dogs and sausages, as they contain nitrites that are associated with inflammation and chronic disease.\u003c\/p\u003e\n\u003cp\u003eThe Tao of Nutrition by Dr. Maoshing Ni and Cathy McNease:\u003c\/p\u003e\n\u003cp\u003e* Restlessness and emotional instability: Make a tea of wheat bran, licorice root, and dates. Drink three times daily until symptoms are relieved.\u003c\/p\u003e\n\u003cp\u003eLIFESTYLE INSTRUCTIONS\u003c\/p\u003e\n\u003cp\u003e* If insomnia is related to work or stress, advise the patient not to work in the bedroom and remove anything that may be a reminder of the office or work. A warm bath or light snack before bedtime may also be helpful.\u003c\/p\u003e\n\u003cp\u003e* Regular exercise, adequate rest, and normal sleep patterns are beneficial for stress reduction.\u003c\/p\u003e\n\u003cp\u003e* Relax the mind and the body through meditation, yoga, breathing exercises, imagery exercises, and other activities such as tai chi chuan [tai ji chuan] and qi gong.\u003c\/p\u003e\n\u003cp\u003e* Get away from daily routines to do something enjoyable to relieve stress whenever possible. Laughter really is the best medicine.\u003c\/p\u003e\n\u003cp\u003e* Noise can be disturbing to mental health and cause stress. Noise greater than 65-decibels can cause psychological disturbance, greater than 90-decibels can cause emotional damages, and greater than 120-decibels can cause nervous system and hearing damages.\u003c\/p\u003e\n\u003cp\u003e* Sleep by 10 p.m. In TCM, 11 p.m. to 1 a.m. is when the yin shifts to yang. It is crucial for the body to be at rest during this time for optimal health.\u003c\/p\u003e\n\u003cp\u003eCASE STUDIES\u003c\/p\u003e\n\u003cp\u003e* C.K., a 54-year-old female, presented with obsessive compulsive disorder, anxiety and over thinking. Patient had been taking Celexa (citalopram) and Effexor (venlafaxine) for many years for anxiety and depression. The practitioner diagnosed the condition as disturbance of the shen (spirit). She was treated with Calm (ES), four capsules three times daily based upon her small frame and weight of 120 pounds. She was also recommended to take vitamin B12. After one year of taking the herbs and returning to the Western drugs occasionally, the patient began to handle and recognize her emotions and no longer uses the drugs. In her five-year follow-up treatment, she was only taking two capsules two times daily, doing her spiritual work, breathing properly, and was much happier. Submitted by N.H., Chatsworth, California.\u003c\/p\u003e\n\u003cp\u003e* A 65-year-old female patient, whose husband had recently died and was left to run their business, presented with high blood pressure and was not interested in Western medicine for treatment. Her blood pressure was 160\/92 mmHg and her heart rate was 78 beats per minute. She frequently experienced stress at work, sleeping difficulties, and would wake up feeling very anxious during the night. The practitioner diagnosed the condition as Liver qi stagnation and phlegm fire. The patient was treated with Calm (ES) four capsules three times daily. After seeing results from the herbs, her Western doctor stopped pushing her to take the Western drugs. Occasionally the patient experienced an increase in her blood pressure due to stress, and would come in to receive acupuncture treatment. The patient was also encouraged to exercise and lose weight to help with her overall health. Submitted by L.W., Arroyo Grande, California.\u003c\/p\u003e\n\u003cp\u003e* P.I., a 46-year-old female, presented with spotting and uterine bleeding between menstrual cycles, which were irregular short cycles ranging from 15 to 27 days long. She had been experiencing heavy bleeding, no clots during her cycles, night sweats, and chronic anxiety, which was worse before her menses. Her Western diagnosis was perimenopausal syndrome with chronic anxiety; the TCM diagnosis was Liver and Kidney yin deficiencies with deficiency heat, blood stagnation, Liver qi stagnation, and shen (spirit) disturbance. The practitioner prescribed Calm (ES), two grams three times a day and has been taking this formula for anxiety the past two years. In addition, she was also prescribed Nourish and Notoginseng 9, same dosage as the other formula, for six months to stop the uterine bleeding. Notoginseng 9 successfully stopped the irregular bleeding and night sweats, which had been gradually reduced over the six month period. Her periods have returned to normal with light flow and her anxiety is also much better ever since adding Nourish. The patient had excellent wellness and lifestyle habits, including her diet and exercise, and she was very compliant with taking her herbs. Submitted by E.Z., Portland, Oregon.\u003c\/p\u003e\n\u003cp\u003e* J.K., a 35-year-old male, presented with alcoholism, with a constant urge to drink. However, he did not want to attend AA meetings. Other than this, the patient was considered to be healthy. The patient had also just previously quit smoking cold turkey. For treatment the patient was given Calm (ES) and Liver DTX in conjunction with receiving acupuncture. As a result, the patient reported that he no longer had the urge to drink. The practitioner had also counseled the patient that this was not a stand alone treatment for alcoholism and advised the patient to go seek more help. Submitted by B.L., Fort Myers, Florida.\u003c\/p\u003e\n\u003cp\u003e* J.H., a 37-year-old female, presented with anxiety, depression and addiction symptoms. There was also a history of ulcerative colitis. Pulse was weak and wiry, and her tongue had a red tip with a center crack and white coat. The practitioner diagnosed this condition as qi and blood stagnation, Liver qi stagnation, and shen (spirit) disturbance. For treatment the patient was prescribed a combination of Astringent Complex, Calm (ES), and Gui Pi Tang (Restore the Spleen Decoction). The patient had completely changed for the better as she had stopped taking Western medication, quit smoking, and felt stable and happy after two months of treatment. Submitted by T.W., Perrysburg, Ohio.\u003c\/p\u003e\n\u003cp\u003e* M.D., a 41-year-old female, presented with manic depressive disorder. PMS symptoms, constipation and a history of depression and addiction were also noted. Pulse was wiry and her tongue had a red tip. The practitioner diagnosed this condition as Liver qi stagnation with heat disturbing the shen (spirit) and consuming fluids. Upon diagnosis, the patient was given Calm (ES) along with Zhi Zi (Fructus Gardeniae) and Da Huang (Radix et Rhizoma Rhei). With taking the herbs the patient had stated she had never felt this good naturally before. She was very thankful. Submitted by T.W., Perrysburg, Ohio.\u003c\/p\u003e\n\u003cp\u003e* A.D., a 58-year-old female, presented with nervousness, along with worrisome scattered thoughts throughout the day. It was noted that the patient was anorexic as well. Blood pressure was 112\/74 mmHg and heart rate was 60 beats per minute. The practitioner diagnosed this condition as Spleen and Heart qi deficiencies with Liver qi stagnation agitating the shen (spirit). The patient was prescribed Calm (ES) to take as she was dealing with her mother's health condition and their strained relationship as well. During the times she took the Calm (ES), the patient responded very well and continues to use them during times of stress. Submitted by L.H., Chicago, Illinois.\u003c\/p\u003e\n\u003cp\u003e* L.H., a 43-year-old female, presented with anxiety symptoms consisting of restless thoughts, insomnia and waking up at 3 a.m. almost every night. It was noted that the patient's anxiety was related to a business situation involving traveling and that she felt very overwhelmed at work. Blood pressure was 110\/72 mmHg and heart rate was 62 beats per minute. The practitioner diagnosed the condition as Liver qi stagnation with fire harassing the shen (spirit). Upon diagnosis, Calm (ES) was prescribed and she was directed to take it before and during the business trip. After taking the herbs, the patient experienced immediate effect of relief from stress and insomnia. The herbs also gave her a peaceful feeling with her work situation. Submitted by L.H., Chicago, Illinois.\u003c\/p\u003e\n\u003cp\u003e* S.L., a 42-year-old female, presented with a sensation of insanity, grief and sadness. Objective findings were wide-opened eyes and shaking hands. The practitioner diagnosed this condition as disturbance of the shen (spirit). Upon diagnosis the patient was directed to take Calm (ES) as needed. As a result of taking the herbs for four days, the patient noticed herself feeling calmer and less hysterical. However, the patient had noted that in order for Calm (ES) to be effective, she needed to take it several times a day. Submitted by S.L., Yuma, Arizona.\u003c\/p\u003e\n\u003cp\u003e* A.L., a 36-year-old female, presented with PMS symptoms including stomach cramping, moodiness and breast tenderness. Pulse was wiry and the tip and sides of her tongue were both slightly red. The TCM diagnosis was Liver qi stagnation. For treatment, Calm (ES) was prescribed at two capsules two times a day. As a result of taking the herbs, it was noticed one week before her next menstrual cycle that the patient felt more relaxed, with no breast tenderness or cramping. Submitted by M.P., Muskego, Wisconsin.\u003c\/p\u003e\n\u003cp\u003e* W.Y., a 62-year-old male, presented with insomnia due to stress and anxiety, which caused him to wake two to three times per night. Objective findings included red cheeks and purple lips. The TCM diagnosis was blood stagnation with Liver fire. For treatment Circulation was prescribed to treat the blood stagnation as well as Calm (ES) to treat the anxiety. Both were prescribed at a dosage of 2 capsules two times a day. Within the first week of taking the herbs the patient's sleep had improved to waking up only once during the night. His legs were still blue so the dosage of Circulation was increased. Submitted by M.P., Muskego, Wisconsin.\u003c\/p\u003e\n\u003cp\u003e* A.B., a 22-year-old female, presented with anxiety and fear of failure. Additional symptoms she had been experiencing were depression, insomnia, and poor eating habits. It was noted that her shen (spirit) was not settled and she had dysglycemia. The practitioner diagnosed this condition as Liver qi stagnation and Spleen qi deficiency; Western diagnosis was low self-esteem along with low caloric diet. Calm (ES) was prescribed to take during the day and then Calm ZZZ to take at night. After two weeks she was then instructed to take Schisandra ZZZ at night and Shine during the day. Bu Zhong Yi Qi Tang (Tonify the Middle and Augment the Qi Decoction) was taken as well until she began eating at regular intervals. After one month of taking the herbs, the insomnia had resolved and regular sleeping habits were occurring. In addition, her depression was lifted. She started experiencing major changes in attitude, life purpose and direction. Six weeks later she maintained her results by taking Calm. The anxiety had also reduced, only being anxious during stressful situations, which she had been resolving. She had also established regular eating habits, her energy had improved and her menses became regular without pain. Overall, the patient was very pleased with the outcome of taking the herbs. Submitted by N.T., Bethesda, Maryland.\u003c\/p\u003e\n\u003cp\u003e* S.B., a 49-year-old female, presented with mood swings. It was also noted that she had night sweats and ringing in the ears. She was borderline diabetic, which she managed well through her diet. The practitioner diagnosed this condition as Kidney and Liver yin deficiencies with Liver qi stagnation. Calm (ES) was prescribed in combination with Zhi Bai Di Huang Wan (Anemarrhena, Phellodendron, and Rehmannia Pill). By the end of the first week taking the herbs, she had reported feeling less volatile, a decrease in night sweating, and was sleeping more deeply. Submitted by N.V., Muir Beach, California.\u003c\/p\u003e\n\u003cp\u003e* L.L., a 56-year-old female, presented with frustration, anger and sadness over losing her home in the hurricanes. She was unable to move through these emotions. She was also diagnosed with hypertension, high cholesterol, and post-traumatic stress syndrome recently, and refused to take medications. Her blood pressure was 138\/78 mmHg and her heart rate was 82 beats per minute. She also suffered from headaches in the temporal region and the vertex. Other symptoms included twitching of the eyes, agitation, red eyes, and a scalloped tongue with thick yellow tongue coating. The TCM diagnoses were damp-heat in the Liver and Gallbladder, Kidney yin deficiency, and excess fire and wind rising. She was prescribed the following formulas: Calm (ES) at 1 to 3 capsules, as needed, Cholisma at 4 capsules twice daily, and Gentiana Complex at 5 capsules twice daily. The patient gained control of her emotions immediately after taking Calm (ES). Blood pressure gradually reduced over time to 120\/72 mmHg. The practitioner commented that the combination of these formulas is phenomenal. Submitted by M.H., West Palm Beach, Florida.\u003c\/p\u003e\n\u003cp\u003e* A 49-year-old female social worker presented with stress, anxiety, dizziness and irregular menses. The patient reported occasional irritability, hot flashes, night sweats and dysmenorrhea. Dry eyes and muscle cramps were also present. The patient was diagnosed with Kidney and Liver yin deficiencies with Liver qi stagnation. With Balance (Heat) and Calm (ES), the patient experienced a reduction of hot flashes and had less irritability, stress, anxiety and dizziness. She also stated that she slept better and her menses were not as painful. The practitioner concluded that Balance (Heat) and Calm (ES) were an excellent combination for the condition. Submitted by D.M., Raton, New Mexico.\u003c\/p\u003e\n\u003cp\u003e* A 44-year-old female police officer presented with chronic headaches located in the occipital\/temporal regions. She stated that stress aggravated the problem. There was acute tenderness at the Fengchi (GB 20) area as well as in the cervical spine. She also experienced pain on her zygoma. The practitioner diagnosed the condition as qi and blood stagnation in Gallbladder, Urinary Bladder, and Small Intestine channels in addition to myofascial syndrome, which was stress-induced because of the nature of her job. She was treated with Corydalin (AC), Neck \u0026amp; Shoulder (AC) and Calm (ES), which were all so effective that they subsequently replaced her medication, Imitrex (sumatriptan). The practitioner concluded that a critical aspect in the treatment was to assist the patient in coping with stress, which in turn made the herbal treatment more effective. Submitted by S.C., La Crescenta., California.\u003c\/p\u003e\n\u003cp\u003e* An 18-year-old female presented with vivid visual hallucinations at night, mainly when going alone from her car to the house. The Western diagnosis was paranoia with visual hallucination; the TCM diagnosis was Liver qi stagnation with shen (spirit) disturbance. The practitioner prescribed three capsules of Calm (ES), three times daily for two weeks, and taught the patient to engage in positive visual imagery and mental clarification. After the integrative therapies, the patient reported that her hallucinations and fears had resolved. Submitted by C.L., Chino Hills, California.\u003c\/p\u003e\n\u003cp\u003e* A 40-year-old male presented with severe insomnia, restlessness, and hyperactivity. Tongue body appeared red while his pulse felt rapid and wiry. Western assessment of his condition was schizophrenia. The TCM diagnosis was Heart fire and Liver fire. Within a week of taking Calm (ES), his sleep time increased from 2 to 3 hours a night to 7 to 8 hours a night. His restlessness and hyperactivity also subsided. Submitted by T.G., Albuquerque, New Mexico.\u003c\/p\u003e\n\u003cp\u003e* M.C., a 53-year-old female, presented with anxiety. She was very anxious and fearful of flying. Otherwise healthy, she had to take her son up north to begin college and had to fly, and came to my office for treatment. Her blood pressure was 120\/78 mmHg and her heart rate was 76 beats per minute. The TCM diagnosis was Liver fire. Calm (ES) was prescribed at 4 to 6 capsules before the flight. She reported later that she took 4 capsules one hour before her flight, and that her anxiety was under control. She was able to fly out more often to see her son as she felt she could handle the flights when she takes Calm (ES). Submitted by M.H., West Palm Beach, Florida.\u003c\/p\u003e\n\u003cp\u003e* A 53-year-old male miner presented with insomnia, depression, stress, anxiety and fatigue. He had difficulty falling asleep, which was aggravated by relentless worrying. Other symptoms included palpitations and occasional dizziness. A choppy pulse and a pale tongue were present, along with a pale complexion. The practitioner diagnosed the condition as Heart and Spleen blood deficiency. After the initial treatment, his sleep improved from two to three hours per night to five to six hours per night. The patient was no longer fatigued and felt much calmer. Because of his occupation and the nature of his condition, he was unable to take the Western medication since drowsiness was one side effect. The combination of Schisandra ZZZ and Calm (ES) made it possible to manage his condition with no known side effects. The practitioner recommended continuous application of the herbal combination of Schisandra ZZZ and Calm (ES) for his medical condition. Submitted by D.M., Raton, New Mexico.\u003c\/p\u003e\n\u003cp\u003e* A 78-year-old female with a past history of stroke presented with memory loss, insomnia, and nightmares. She was easily frightened and frequently woke up in the middle of the night because of her dreams. Her Western medical diagnosis was dementia. The TCM diagnosis included qi and blood stagnation, Liver and Kidney yin deficiency, and Heart fire. She was given Calm (ES) and Neuro Plus. After taking the herbs for approximately one month, the patient was able to recall the practitioner's name for the very first time! In addition, her sleep, mood, complexion, and energy level improved greatly. The patient was much calmer and less irritable. Despite the fact that she still did not know the name of her town or the correct month, there were many improvements in all other areas. The practitioner concluded that the combination of Calm (ES) and Neuro Plus has enhanced the patient's quality of life. Submitted by P.R., Encinitas, California.\u003c\/p\u003e\n\u003cp\u003e* B.B., a 51-year-old female, presented with daily, moderate headaches. She suffered from breast tenderness and a headache that worsened before each period. She also had insomnia and would waken and stay awake for an hour, several times a night. She suffered from irritability that may have arisen from her recent quitting of tobacco smoking. Her tongue was purplish red; her pulse was rapid and wiry. The TCM diagnosis was Liver fire and Liver qi stagnation. Jia Wei Xiao Yao San (Augmented Rambling Powder) and Calm (ES) were prescribed at 2 grams each, daily. After taking the herbs, the patient reported the breast soreness was gone. Her headache began to diminish, especially after she was past nicotine detox. Irritability was also greatly reduced. The patient continued taking the herbs for a year, and noticed that if she stopped taking the herbs, the irritability would return but not the headache or sore breasts. She continues with the formulas at 1 gram per day each, and is very impressed with the results. Submitted by C.D., Phoenix, Oregon.\u003c\/p\u003e\n\u003cp\u003ePHARMACOLOGICAL AND CLINICAL RESEARCH\u003c\/p\u003e\n\u003cp\u003eNonstop stress in the modern world places a tremendous burden on the mind and the body to always function in a heightened and alarmed state. Over time, the mind and the body are unable to relax, leading to a wide variety of dysfunction throughout the body, including brain (feelings and emotions), heart (hypertension, arrhythmia, atherosclerosis, coronary artery disease), muscles (stiffness and pain), stomach (acid reflux, peptic ulcer disease, irritable bowel syndrome), and immune system (weakened immune system, frequent infection). Therefore, optimal treatment requires use of herbs to rescue the mind from stress and restore the body to its optimal health.\u003c\/p\u003e\n\u003cp\u003eCalm (ES) contains herbs with adaptogenic effects to help the patients cope with nonstop stress. Bai Zhu (Rhizoma Atractylodis Macrocephalae) and Fu Shen (Poria Paradicis) have an adaptogenic effect to help the patients deal with physical stress by enhancing duration and relieving restlessness.[5,6] Chai Hu (Radix Bupleuri), Gou Teng (Ramulus Uncariae cum Uncis), Suan Zao Ren (Semen Ziziphi Spinosae), Da Zao (Fructus Jujubae), Xie Cao (Radix et Rhizoma Valerianae) and Zhi Zi (Fructus Gardeniae) have calming effects on the brain to help the patients manage mental stress by promoting relaxation and improving sleeping.[7,8,9,10,11,12] To improve mental functions and ameliorate memory impairment, herbs are used in this formula for their positive cognitive effect, such as Da Zao (Fructus Jujubae) and Gan Cao (Radix et Rhizoma Glycyrrhizae).[13,14]\u003c\/p\u003e\n\u003cp\u003eIn addition, herbs with anxiolytic and antidepressant effects are used in this formula to combat stress, anxiety and depression. Suan Zao Ren (Semen Ziziphi Spinosae) and Xi Yang Shen (Radix Panacis Quinquefolii) both have an anxiolytic effect to relieve stress and anxiety.[15,16] Huang Qin (Radix Scutellariae) exerts its anxiolytic effect through positive allosteric modulation of the GABA(A) receptor complex.[17] Xie Cao (Radix et Rhizoma Valerianae) has both anxiolytic and antidepressant activities.[18] According to neurobiological research, administration of Xie Cao (Radix et Rhizoma Valerianae) and its active valerenic acid is associated with a significant reduction in anxious behavior. The herb and its active compounds exert their anxiolytic effects by interacting with the GABA(A)-ergic system, a mechanism of action similar to the benzodiazepine drugs.[19]\u003c\/p\u003e\n\u003cp\u003eTo restore normal functions of the heart, Calm (ES) has herbs with various cardiovascular and circulatory functions. In one laboratory study, intravenous injection of Dang Gui (Radix Angelicae Sinensis) was associated initially with an inhibitory influence on the heart, followed by a negative chronotropic effect and a positive inotropic effect. It improves overall blood circulation by decreasing the whole blood specific viscosity, or improving the hemorrheological changes in \"blood stagnation.\" It also has an antiarrhythmic effect, especially against arrhythmia induced by epinephrine, cardiac glycosides, aconitine, and barium chloride. Administration of Dang Gui (Radix Angelicae Sinensis) is associated with reduction of plasma cholesterol and triglyceride levels, and a decreased risk of atherosclerosis, as demonstrated in laboratory studies.[20,21,22,23] Zhi Zi (Fructus Gardeniae) has demonstrated marked antihypertensive action in numerous studies. One proposed mechanism of this hypotensive effect is its stimulation of the parasympathetic nervous system.[24] Zhi Gan Cao (Radix et Rhizoma Glycyrrhizae Praeparata cum Melle) has shown marked effectiveness in treating subjects with palpitations and artificially-induced arrhythmia.[25,26] Chai Hu (Radix Bupleuri) has an antihyperlipidemic effect, and has been shown to lower total cholesterol, low-density lipoprotein (LDL) and triglyceride levels.[27] Lastly, Gou Teng (Ramulus Uncariae cum Uncis) has a moderate and prolonged antihypertensive effect to treat hypertension by decreasing heart rate and reducing peripheral vascular resistance.[28,29] Gou Teng (Ramulus Uncariae cum Uncis) also has a cardioprotective effect for prevention and treatment of vascular proliferative disorders, such as atherosclerosis and restenosis after angioplasty.[30]\u003c\/p\u003e\n\u003cp\u003eCalm (ES) contains many herbs with analgesic and anti-inflammatory effects to help the body cope with muscle aches and pain due to stress. Dang Gui (Radix Angelicae Sinensis) has both analgesic and anti-inflammatory effects with potency comparable to or greater than acetylsalicylic acid.[31,32] It has been used successfully to treat low back and leg pain,[33] vascular headache,[34] migraine headache,[35] and the general complaint of pain.[36] Bai Zhu (Rhizoma Atractylodis Macrocephalae) also has anti-inflammatory activity and its mechanism of action is attributed to the inhibition of tumor necrosis factor-alpha (TNF-α) and nitric oxide production.[37] Lastly, Chai Hu (Radix Bupleuri) demonstrates both analgesic and anti-inflammatory functions,[38,39] and the saikosaponins appear to be the main compounds for these actions.[40] Huang Qin (Radix Scutellariae) exhibits significant and potent anti-inflammatory activity via inhibition of nitric oxide, cyclo-oxygenase-2, prostaglandin E2, and proinflammatory cytokines.[41] Finally, Chuan Xiong (Rhizoma Chuanxiong) illustrates an anti-inflammatory effect through its inhibitory activity on TNF-α production and bioactivity.[42] Chuan Xiong (Rhizoma Chuanxiong) has been used successfully to treat many different types of headaches.[43,44,45]\u003c\/p\u003e\n\u003cp\u003eTo alleviate adverse effect of stress on the digestive system, Calm (ES) contains many herbs with gastroprotective effects. Bai Zhu (Rhizoma Atractylodis Macrocephalae) has a dual effect to regulate the digestive tract,[46] and is effective to treat either constipation or diarrhea.[47,48] Mu Li (Concha Ostreae) has a significant effect to neutralize gastric acid, and is commonly used to treat gastric and duodenal ulcers.[49,50] Da Huang (Radix et Rhizoma Rhei) has a remarkable laxative and purgative effect, as it works directly on the large intestine to increase peristalsis and induce bowel movements.[51] Gan Cao (Radix et Rhizoma Glycyrrhizae) has a proven effect to prevent and treat peptic ulcers. The mechanisms of this action include inhibition of gastric acid secretion, binding and deactivation of gastric acid, and promotion of recovery from ulceration.[52] According to one study, 100 patients with gastric or duodenal ulcers were treated with Gan Cao (Radix et Rhizoma Glycyrrhizae) extract with 90% rate of effectiveness.[53] Another study also reported good results using Gan Cao (Radix et Rhizoma Glycyrrhizae) to treat patients with peptic ulcers. The treatment protocol was to administer 2.5 to 5 grams of powdered Gan Cao (Radix et Rhizoma Glycyrrhizae) three times daily for 3 to 4 weeks.[54]\u003c\/p\u003e\n\u003cp\u003eTo enhance the immune system and maintain optimal health, many herbs with immunostimulant effects are used in this formula. Chai Hu (Radix Bupleuri) stimulates both humoral and cellular immunity.[55] Dang Gui (Radix Angelicae Sinensis) increases the phagocytic activity of the macrophages.[56] Lastly, Bai Zhu (Rhizoma Atractylodis Macrocephalae) increases the activity of the macrophages and reticuloendothelial system, and elevates the number of white blood cells, lymphocytes, and IgG.[57,58]\u003c\/p\u003e\n\u003cp\u003eIn summary, Calm (ES) is an excellent formula to relax the mind and restore the body to its optimal health.\u003c\/p\u003e\n\u003cp\u003eCOMPARATIVE ANALYSIS\u003c\/p\u003e\n\u003cp\u003eStress and anxiety are two of the most common emotional disorders. Clinical signs and symptoms include recurrent and intrusive thoughts, insomnia, disturbed sleep, illusions, hallucinations, difficulty concentrating, hypervigilance, restlessness, anger, and irritability.\u003c\/p\u003e\n\u003cp\u003ePharmaceutical drug treatment for stress and anxiety focuses primarily on the use of sedative and hypnotic drugs, such as Valium (diazepam) and Ativan (lorazepam). Though these drugs are very potent and have an immediate effect to sedate patients, they do not address the underlying conditions. Furthermore, long-term use of these medications are associated with many side effects, including drowsiness, dizziness, tiredness, blurred vision, changes in sex drive or ability, shuffling walk, persistent, fine tremor or inability to sit still, difficulty breathing or swallowing, severe skin rash, yellowing of the skin or eyes, irregular heartbeat, and addiction. Therefore, these drugs should only be used when necessary, and only for a short period of time.\u003c\/p\u003e\n\u003cp\u003eUse of herbs is extremely effective to treat stress and anxiety. Herbs regulate mood and emotions, and alleviate stress and anxiety by enhancing the body's own ability to deal with these external factors. Unlike drugs that have an immediate effect to treat stress and anxiety by sedating the mind and decreasing its responsiveness, herbs do not have an immediate effect, and require two or more weeks of continuous use to gradually treat these conditions. In contrast, one of the main advantages of herbs is they are safe and natural, and do not have negative side effects like drugs.\u003c\/p\u003e\n\u003cp\u003eStress and anxiety are two very common disorders. While drugs and herbs are both effective, they have contrasting differences of benefits and risks. While drugs are more effective for short-term treatment, herbs are more successful for long-term management. Furthermore, counseling (behavioral and psychotherapy) is extremely important toward the understanding of, and complete recovery from, these conditions.\u003c\/p\u003e\n\u003cp\u003e[1] Chan K, Lo AC, Yeung JH, Woo KS. Journal of Pharmacy and Pharmacology 1995 May;47(5):402-6.\u003c\/p\u003e\n\u003cp\u003e[2] Pharmacotherapy 1999 July;19(7):870-876.\u003c\/p\u003e\n\u003cp\u003e[3] European Journal of Drug Metabolism and Pharmacokinetics 1995; 20(1):55-60.\u003c\/p\u003e\n\u003cp\u003e[4] Balch, JF. et al. Prescription for Nutritional Healing. Avery Publishing Group. 1997.\u003c\/p\u003e\n\u003cp\u003e[5] Xin Yi Yao Xue Za Zhi (New Journal of Medicine and Herbology), 1974; 8:13.\u003c\/p\u003e\n\u003cp\u003e[6] Zhong Yao Da Ci Dian (Dictionary of Chinese Herbs), 1977:1596.\u003c\/p\u003e\n\u003cp\u003e[7] Zhong Yao Yao Li Yu Ying Yong (Pharmacology and Applications of Chinese Herbs), 1983; 888.\u003c\/p\u003e\n\u003cp\u003e[8] Zhong Yao Yao Li Yu Ying Yong (Pharmacology and Applications of Chinese Herbs), 1983; 786.\u003c\/p\u003e\n\u003cp\u003e[9] Chang Yong Zhong Yao Xian Dai Yan Jiu Yu Lin Chuan (Recent Study \u0026amp; Clinical Application of Common Traditional Chinese Medicine), 1995; 489:491.\u003c\/p\u003e\n\u003cp\u003e[10] Cao JX, Zhang QY, Cui SY, Cui XY, Zhang J, Zhang YH, Bai YJ, Zhao YY. Hypnotic effect of jujubosides from Semen Ziziphi Spinosae. Department of Pharmacology, Peking University, School of Basic Medical Science, 38 Xueyuan Lu, Beijing 100191, China. J Ethnopharmacol. 2010 Jul 6;130(1):163-6.\u003c\/p\u003e\n\u003cp\u003e[11] Xian Dai Zhong Yao Yao Li Xue (Contemporary Pharmacology of Chinese Herbs), 1997; 1092.\u003c\/p\u003e\n\u003cp\u003e[12] Jiang Su Yi Yao (Jiangsu Journal of Medicine and Herbology), 1976; (1):28.\u003c\/p\u003e\n\u003cp\u003e[13] Heo HJ, Park YJ, Suh YM, Choi SJ, Kim MJ, Cho HY, Chang YJ, Hong B, Kim HK, Kim E, Kim CJ, Kim BG, Shin DH. Effects of oleamide on choline acetyltransferase and cognitive activities. Biosci Biotechnol Biochem. 2003 Jun;67(6):1284-91.\u003c\/p\u003e\n\u003cp\u003e[14] Zhu Z, Li C, Wang X, Yang Z, Chen J, Hu L, Jiang H, Shen X. 2,2',4'-trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice. J Neurochem. 2010 Jul;114(2):374-85.\u003c\/p\u003e\n\u003cp\u003e[15] Peng WH, Hsieh MT, Lee YS, Lin YC, Liao J. Anxiolytic effect of seed of Ziziphus jujuba in mouse models of anxiety. Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan, PR China. J Ethnopharmacol. 2000 Oct;72(3):435-41.\u003c\/p\u003e\n\u003cp\u003e[16] Wei XY, et al. Anxiolytic effect of saponins from Panax quinquefolium in mice. Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, PR China. J Ethnopharmacol. 2007 May 22;111(3):613-8.\u003c\/p\u003e\n\u003cp\u003e[17] Hui KM, Huen MS, Wang HY, Zheng H, Sigel E, Baur R, Ren H, Li ZW, Wong JT, Xue H. Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi. Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China. Biochem Pharmacol. 2002 Nov 1;64(9):1415-24.\u003c\/p\u003e\n\u003cp\u003e[18] Hattesohl M, Feistel B, Sievers H, Lehnfeld R, Hegger M, Winterhoff H. Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties. Department of Pharmacology and Toxicology, Universitätsklinikum Münster, Westfälische Wilhelms-Universität Münster, Domagkstr. 12, 48149 Münster, Germany. Phytomedicine. 2008 Jan;15(1-2):2-15.\u003c\/p\u003e\n\u003cp\u003e[19] Murphy K, Kubin ZJ, Shepherd JN, Ettinger RH. Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. Department of Psychology, Eastern Oregon University, LaGrande, OR 97850, USA. Phytomedicine. 2010 Jul;17(8-9):674-8.\u003c\/p\u003e\n\u003cp\u003e[20] Jiang Su Zhong Yi (Jiangsu Chinese Medicine), 1965; (3):22.\u003c\/p\u003e\n\u003cp\u003e[21] Xue, JX. et al. Effects of the combination of astragalus membranaceus (Fisch.) Bge. (AM), angelica sinensis (Oliv.) Diels (TAS), cyperus rotundus L. (CR), ligusticum chuanxiong Hort (LC) and paeonia veitchii lynch (PV) on the hemorrheological changes in \"blood stagnating\" rats. Chung Kuo Chung Yao Tsa Chih; 19(2):108-10, 128. 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Corynoxeine isolated from the hook of Uncaria rhynchophylla inhibits rat aortic vascular smooth muscle cell proliferation through the blocking of extracellular signal regulated kinase 1\/2 phosphorylation. Biol Pharm Bull. 2008 Nov;31(11):2073-8.\u003c\/p\u003e\n\u003cp\u003e[31] Xin Yi Yao Xue Za Zhi (New Journal of Medicine and Herbology), 1975; (6):34.\u003c\/p\u003e\n\u003cp\u003e[32] Yao Xue Za Zhi (Journal of Medicinals), 1971; (91):1098.\u003c\/p\u003e\n\u003cp\u003e[33] Xin Zhong Yi (New Chinese Medicine), 1980; 2:34.\u003c\/p\u003e\n\u003cp\u003e[34] Hu Bei Zhong Yi Za Zhi (Hubei Journal of Chinese Medicine), 1993; (2):9.\u003c\/p\u003e\n\u003cp\u003e[35] Bei Jing Yi Xue (Beijing Medicine), 1988; 2:95.\u003c\/p\u003e\n\u003cp\u003e[36] Xin Yi Yao Xue Za Zhi (New Journal of Medicine and Herbology), 1976; 12:26.\u003c\/p\u003e\n\u003cp\u003e[37] Li CQ, He LC, Jin JQ. Atractylenolide I and atractylenolide III inhibit Lipopolysaccharide-induced TNF-alpha and NO production in macrophages. Phytother Res. 2007 Apr;21(4):347-53.\u003c\/p\u003e\n\u003cp\u003e[38] Shen Yang Yi Xue Yuan Xue Bao (Journal of Shenyang University of Medicine), 1984; 1(3):214.\u003c\/p\u003e\n\u003cp\u003e[39] Zhong Yao Yao Li Yu Ying Yong (Pharmacology and Applications of Chinese Herbs), 1983; 888.\u003c\/p\u003e\n\u003cp\u003e[40] Yamamoto M., Kumagai A. \u0026amp; Yamamura Y. () Structure and actions of saikosaponins isolated from Bupleurum falcatum L. I. Anti-inflammatory action of saikosaponins. Arzneim Forsch. 1975, 25: 1021-1023.\u003c\/p\u003e\n\u003cp\u003e[41] Kim EH, Shim B, Kang S, Jeong G, Lee JS, Yu YB, Chun M. Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules. Department of Biological Sciences, Seoul National University, Seoul 151-742, Republic of Korea. J Ethnopharmacol. 2009 Nov 12;126(2):320-31.\u003c\/p\u003e\n\u003cp\u003e[42] Liu L, Ning ZQ, Shan S, Zhang K, Deng T, Lu XP, Cheng YY. Phthalide Lactones from Ligusticum chuanxiong inhibit lipopolysaccharide-induced TNF-alpha production and TNF-alpha-mediated NF-kappaB Activation. Planta Med. 2005 Sep;71(9):808-13.\u003c\/p\u003e\n\u003cp\u003e[43] Zhong Xi Yi Jie He Za Zhi (Journal of Integrated Chinese and Western Medicine), 1991; (1):52.\u003c\/p\u003e\n\u003cp\u003e[44] Shan Xi Zhong Yi Za Zhi (Shanxi Journal Chinese Medicine), 1985; 10:447.\u003c\/p\u003e\n\u003cp\u003e[45] Si Chuan Zhong Yi (Sichuan Chinese Medicine), 1996; (11):27.\u003c\/p\u003e\n\u003cp\u003e[46] Chang Yong Zhong Yao Cheng Fen Yu Yao Li Shou Ce (A Handbook of the Composition and Pharmacology of Common Chinese Drugs), 1994; 739:742.\u003c\/p\u003e\n\u003cp\u003e[47] Xin Yi Yao Xue Za Zhi (New Journal of Medicine and Herbology), 1978; 4:9.\u003c\/p\u003e\n\u003cp\u003e[48] Shan Dong Zhong Yi Za Zhi (Shandong Journal of Chinese Medicine), 1982; 2:107.\u003c\/p\u003e\n\u003cp\u003e[49] Zhong Yao Xue (Chinese Herbology), 1998; 686:688.\u003c\/p\u003e\n\u003cp\u003e[50] Zhong Yi Za Zhi (Journal of Chinese Medicine), 1983; 3:36.\u003c\/p\u003e\n\u003cp\u003e[51] Zhong Yao Xue (Chinese Herbology), 1998; 251:256.\u003c\/p\u003e\n\u003cp\u003e[52] Zhong Yao Zhi (Chinese Herbology Journal), 1993; 358.\u003c\/p\u003e\n\u003cp\u003e[53] Zhong Hua Nei Ke Xue Za Zhi (Journal of Chinese Internal Medicine), 1960; 3:226.\u003c\/p\u003e\n\u003cp\u003e[54] Zhong Yao Lin Chuan Xin Yong (New Clinical Applications of Chinese Medicine), 2001; 163.\u003c\/p\u003e\n\u003cp\u003e[55] Shang Hai Yi Ke Da Xue Xue Bao (Journal of Shanghai University of Medicine), 1986; 13(1):20.\u003c\/p\u003e\n\u003cp\u003e[56] Zhong Hua Yi Xue Za Zhi (Chinese Journal of Medicine), 1978; 17(8):87.\u003c\/p\u003e\n\u003cp\u003e[57] Jun Shi Yi Xue Jian Xun (Military Medicine Notes), 1977; 2:5.\u003c\/p\u003e\n\u003cp\u003e[58] Xin Yi Yao Xue Za Zhi (New Journal of Medicine and Herbology), 1979; 6:60.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd width=\"10%\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Modern Herbal Formulas","offers":[{"title":"Default Title","offer_id":53132748587119,"sku":null,"price":50.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0726\/8630\/5391\/files\/CalmES.jpg?v=1779321563"},{"product_id":"calm-zzz-stress-insomnia-and-an-overactive-mind","title":"Calm ZZZ = Stress, insomnia, and an overactive mind","description":"\u003cp\u003e\u003cb\u003eCalm ZZZ\u003c\/b\u003e \u003csup\u003e™\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003eStress, insomnia, and an overactive mind in individuals with underlying weakness and deficiencies.\u003c\/p\u003e\n\u003cdiv class=\"WordSection1\"\u003e\n\u003cp\u003e\u003cb\u003eCLINICAL APPLICATIONS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* \u003cb\u003eChronic and constant stress, anxiety and depression with underlying deficiency\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* \u003cb\u003eInsomnia\u003c\/b\u003e \u003cb\u003ewith difficulty falling or staying asleep\u003c\/b\u003e in patients who are stressed or have things on their minds\u003c\/p\u003e\n\u003cp\u003e* \u003cb\u003eType A personality\u003c\/b\u003e with excessive competitive drive, impatience, sense of urgency without the body strength and constitution to cope with their stress\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWESTERN THERAPEUTIC ACTIONS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* Anxiolytic effect to relieve stress and anxiety\u003c\/p\u003e\n\u003cp\u003e* Antidepressant function to lift emotions\u003c\/p\u003e\n\u003cp\u003e* Sedative and hypnotic benefits to treat insomnia\u003c\/p\u003e\n\u003cp\u003e* Muscle-relaxant action to alleviate tension and stiffness\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCHINESE THERAPEUTIC ACTIONS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* Calms the \u003ci\u003eshen\u003c\/i\u003e (spirit)\u003c\/p\u003e\n\u003cp\u003e* Regulates Liver qi\u003c\/p\u003e\n\u003cp\u003e* Sedates Liver fire\u003c\/p\u003e\n\u003cp\u003e* Tonifies the deficiencies\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eDOSAGE\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eTake 3 to 4 capsules three times daily for stress, anxiety, emotional instability and similar mental disorders. For insomnia, another dose may be taken 30 minutes before bedtime. This formula is safe for long-term use.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eINGREDIENTS\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection2\"\u003e\n\u003cp\u003e\u003ci\u003eBai Shao\u003c\/i\u003e (Radix Paeoniae Alba)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eChai Hu\u003c\/i\u003e (Radix Bupleuri)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eDa Zao\u003c\/i\u003e (Fructus Jujubae)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eDeng Xin Cao\u003c\/i\u003e (Medulla Junci)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eFu Shen\u003c\/i\u003e (Poria Paradicis)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eGan Cao\u003c\/i\u003e (Radix et Rhizoma Glycyrrhizae)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eGou Teng\u003c\/i\u003e (Ramulus Uncariae cum Uncis)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eHe Huan Hua\u003c\/i\u003e (Flos Albiziae)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eShou Wu Teng\u003c\/i\u003e (Caulis Polygoni Multiflori)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eSuan Zao Ren\u003c\/i\u003e (Semen Ziziphi Spinosae)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eXiang Fu\u003c\/i\u003e (Rhizoma Cyperi)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eXiao Mai\u003c\/i\u003e (Fructus Tritici)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eZhi Mu\u003c\/i\u003e (Rhizoma Anemarrhenae)\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection3\"\u003e\n\u003cp\u003e\u003cb\u003eBACKGROUND\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eNonstop stress in the modern world places a tremendous burden on the mind and the body to always function in a heightened and alarmed state. Overtime, the mind and the body are unable to relax, leading to a wide variety of dysfunctions throughout the body, including brain (feelings and emotions), heart (hypertension, arrhythmia, atherosclerosis, coronary artery disease), muscles (stiffness and pain), stomach (acid reflux, peptic ulcer disease, irritable bowel syndrome), and immune system (weakened immune system, frequent infection). Therefore, optimal treatment requires use of herbs to rescue the mind from stress and restore the body to its optimal health.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eFORMULA EXPLANATION\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e is designed to treat individuals who are under constant stress but also have a deficient constitution. This is one of the best formulas to treat \u003ci\u003eshen\u003c\/i\u003e (spirit) disturbance both during the day and at night. \u003ci\u003eShen\u003c\/i\u003e (spirit) disturbance during the day can manifest as stress, anxiety and emotional instability. \u003ci\u003eShen\u003c\/i\u003e (spirit) disturbance at night manifests as insomnia with difficulty falling asleep and\/or staying asleep. Many of these patients will also have underlying deficiencies as a result of Liver excess consuming yin and body fluids on a long-term basis. Therefore, optimal treatment requires use of herbs to calm the \u003ci\u003eshen\u003c\/i\u003e (spirit), regulate Liver qi, sedate Liver fire, and tonify the deficiencies.\u003c\/p\u003e\n\u003cp\u003eIn this formula, \u003ci\u003eChai Hu\u003c\/i\u003e (Radix Bupleuri) and \u003ci\u003eXiang Fu\u003c\/i\u003e (Rhizoma Cyperi) are used to regulate qi circulation and relieve Liver qi stagnation. \u003ci\u003eGou Teng\u003c\/i\u003e (Ramulus Uncariae cum Uncis) calms Liver yang, \u003ci\u003eDeng Xin Cao\u003c\/i\u003e (Medulla Junci) sedates Heart fire, and \u003ci\u003eZhi Mu\u003c\/i\u003e (Rhizoma Anemarrhenae) clears deficiency fire. These three herbs treat the excess aspects of \u003ci\u003eshen\u003c\/i\u003e (spirit) disturbance and relieve irritability.\u003c\/p\u003e\n\u003cp\u003eIn addition, \u003ci\u003eBai Shao\u003c\/i\u003e (Radix Paeoniae Alba), \u003ci\u003eFu Shen\u003c\/i\u003e (Poria Paradicis), \u003ci\u003eSuan Zao Ren\u003c\/i\u003e (Semen Ziziphi Spinosae), \u003ci\u003eHe Huan Hua\u003c\/i\u003e (Flos Albiziae), and \u003ci\u003eShou Wu Teng\u003c\/i\u003e (Caulis Polygoni Multiflori) calm the \u003ci\u003eshen\u003c\/i\u003e (spirit) and relieve stress and anxiety by nourishing the Heart. \u003ci\u003eXiao Mai\u003c\/i\u003e (Fructus Tritici), \u003ci\u003eGan Cao\u003c\/i\u003e (Radix et Rhizoma Glycyrrhizae) and \u003ci\u003eDa Zao\u003c\/i\u003e (Fructus Jujubae) calm the \u003ci\u003eshen\u003c\/i\u003e (spirit) and control emotional instability and prevent the drastic shifting of moods. Together, these eight herbs address the deficiency aspects of \u003ci\u003eshen\u003c\/i\u003e (spirit) disturbance.\u003c\/p\u003e\n\u003cp\u003eIn short, \u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e uses an integrative approach to treat both the excess and deficient aspects of \u003ci\u003eshen\u003c\/i\u003e (spirit) disturbance. Clinical applications include stress, anxiety, emotional disturbance, mental disorders, and insomnia.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCAUTIONS \u0026amp; CONTRAINDICATIONS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* This herbal formula may cause drowsiness in individuals who are sensitive to herbs. Patients are advised not to drive or operate heavy machinery while taking this herbal formula. Similarly, alcohol is not recommended as it may intensify the effect.\u003c\/p\u003e\n\u003cp\u003e* \u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e is \u003cb\u003e\u003ci\u003enot\u003c\/i\u003e\u003c\/b\u003e to be used as \"sleeping pills.\" Do \u003cb\u003e\u003ci\u003enot\u003c\/i\u003e\u003c\/b\u003e ingest a large amount of this formula, as this will only increase the risk of potential side effects, such as drowsiness.\u003c\/p\u003e\n\u003cp\u003e* Allergy warning: \u003ci\u003eXiao Mai\u003c\/i\u003e (Fructus Tritici) used in this product contains wheat. Persons with allergy to wheat should not take this product.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCLINICAL NOTES\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* \u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e is an excellent formula to treat insomnia associated with stress and anxiety. However, it will generally take a few days before this formula nourishes the underlying deficiency and restores the normal sleeping patterns accordingly.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003ePulse Diagnosis by Dr. Jimmy Wei-Yen Chang:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* \u003cb\u003eOutward display of emotional conditions\u003c\/b\u003e (i.e., patients who express how they feel and do not hold their feelings inside): convex and forceful pulse on the left \u003ci\u003eguan\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e* \u003cb\u003eInternalized emotional conditions\u003c\/b\u003e (i.e., patients who hold their feelings inside): concave and deep pulse on the left \u003ci\u003eguan\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eSUPPLEMENTARY FORMULAS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* For mild to moderate cases of stress and anxiety, combine with \u003cb\u003e\u003ci\u003eCalm\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For moderate to severe cases of stress and anxiety, combine with \u003cb\u003e\u003ci\u003eCalm (ES)\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For severe cases of insomnia, combine with \u003cb\u003e\u003ci\u003eSchisandra ZZZ\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For headache, add \u003cb\u003e\u003ci\u003eCorydalin (AC)\u003c\/i\u003e\u003c\/b\u003e or \u003cb\u003e\u003ci\u003eCorydalin (CR)\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For heartburn or gastric ulcers, add \u003cb\u003e\u003ci\u003eGI Care\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For depression, add \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e or \u003cb\u003e\u003ci\u003eShine (DS)\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For constipation, combine with \u003cb\u003e\u003ci\u003eGentle Lax (Deficient)\u003c\/i\u003e\u003c\/b\u003e or \u003cb\u003e\u003ci\u003eGentle Lax (Excess)\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For irritable bowel syndrome (IBS) due to stress, add \u003cb\u003e\u003ci\u003eGI Harmony\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For ulcerative colitis due to stress, add \u003cb\u003e\u003ci\u003eGI Care (UC)\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For menopausal symptoms, combine with \u003cb\u003e\u003ci\u003eBalance (Heat)\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For forgetfulness, add \u003cb\u003e\u003ci\u003eEnhance Memory\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For hypertension, combine with \u003cb\u003e\u003ci\u003eGastrodia Complex\u003c\/i\u003e\u003c\/b\u003e or \u003cb\u003e\u003ci\u003eGentiana Complex\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* To tonify the overall body constitution, combine with \u003cb\u003e\u003ci\u003eImperial Tonic\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eNUTRITION\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* A diet high in calcium, magnesium, phosphorus, potassium, and vitamins B and E is recommended. These vitamins and minerals are easily depleted by stress.\u003c\/p\u003e\n\u003cp\u003e* Encourage the consumption of fruits and vegetables such as apricots, winter melon, asparagus, avocados, bananas and broccoli in addition to brown rice, dried fruit, figs, salmon, garlic, green leafy vegetables, soy products, and yogurt.\u003c\/p\u003e\n\u003cp\u003e* A glass of warm milk with honey before bedtime is helpful for mild insomnia.\u003c\/p\u003e\n\u003cp\u003e* Advise the patient to avoid foods that contain tyramine near bedtime. Tyramine increases the release of the brain stimulant norepinephrine. Food with high tyramine content include: bacon, cheese, chocolate, eggplant, ham, potatoes, sugar, sausage, spinach, and tomatoes.\u003c\/p\u003e\n\u003cp\u003e* Avoid caffeine (coffee, tea, cola, chocolate), tobacco, alcohol and sugar whenever possible.\u003c\/p\u003e\n\u003cp\u003e* Warm and hot natured foods that damage qi and yin should be avoided, such as:\u003c\/p\u003e\n\u003cp\u003e§ certain fruits like mango and durian that produce heat.\u003c\/p\u003e\n\u003cp\u003e§ stimulants like coffee, alcohol, and energy drinks.\u003c\/p\u003e\n\u003cp\u003e§ spicy\/pungent\/aromatic vegetables such as pepper, garlic, onions, basil, rosemary, cumin, funnel, anise, leeks, chives, scallions, thyme, saffron, wormwood, mustard, chili pepper, and wasabi.\u003c\/p\u003e\n\u003cp\u003e* Avoid food and drinks with artificial coloring.\u003c\/p\u003e\n\u003cp\u003e* Consume as few meat products as possible. Do not eat processed meats, such as lunch meats, hot dogs and sausages, as they contain nitrites that are associated with inflammation and chronic disease.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eThe Tao of Nutrition by Dr. Maoshing Ni and Cathy McNease:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* Restlessness and emotional instability: Make a tea of wheat bran, licorice root, and dates. Drink three times daily until symptoms are relieved.\u003c\/p\u003e\n\u003cp\u003e* Insomnia: Boil mulberry tea and drink 1\/2 cup.\u003c\/p\u003e\n\u003cp\u003e* Anxiety and\/or insomnia: Toast 1\/4 cup amaranth in the oven until slightly brown, remove and steep in a cup of hot water for five minutes and sip for immediate relief of anxiety or before bedtime for insomnia.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eLIFESTYLE INSTRUCTIONS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* Regular exercise, adequate rest, and normal sleep patterns are beneficial for stress reduction.\u003c\/p\u003e\n\u003cp\u003e* Relax the mind and the body through meditation, yoga, breathing exercises, imagery exercises, and other activities such as \u003ci\u003etai chi chuan [tai ji chuan]\u003c\/i\u003e and \u003ci\u003eqi gong\u003c\/i\u003e.\u003c\/p\u003e\n\u003cp\u003e* Get away from the daily routine to do something different and enjoyable to relieve stress whenever possible. Laughter really is the best medicine!\u003c\/p\u003e\n\u003cp\u003e* Noise can be disturbing to mental health and cause stress.\u003c\/p\u003e\n\u003cp\u003e* If insomnia is due to overwork, do not work in the bedroom, and remove anything that may be a reminder of the office or work. A warm bath or light snack before bedtime may also be helpful.\u003c\/p\u003e\n\u003cp\u003e* Advise the patients to not worry and to do their best to prepare for upcoming events they know may be stressful. Try to ask for help from friends, family and colleagues when stress in life becomes intolerable.\u003c\/p\u003e\n\u003cp\u003e* Shift outlook on life and look at changes in a positive way and as challenges rather than threats.\u003c\/p\u003e\n\u003cp\u003e* Sleep by 10 p.m. In TCM, 11 p.m. to 1 a.m. is when the yin shifts to yang. It is crucial for the body to be at rest during this time for optimal health.\u003c\/p\u003e\n\u003ch2\u003eCASE STUDIES\u003c\/h2\u003e\n\u003cp\u003e* C.W., a 39-year-old female, presented with difficulty in both falling and staying asleep, which she believed was due to stress. The practitioner diagnosed this condition as Liver qi stagnation and \u003ci\u003eshen\u003c\/i\u003e (spirit) disturbance; the Western diagnosis was insomnia. \u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e was prescribed at three capsules three times a day. After taking the herbs for two weeks, the patient reported being able to sleep for four to six hours undisturbed. She had also mentioned having better personal relationships. Submitted by S.L., Yuma, Arizona.\u003c\/p\u003e\n\u003cp\u003e* M.S., a 49-year-old female, presented with severe muscle spasms on the side of her neck and shoulder area. Objective findings included limited range of motion (ROM). It was mentioned that she had been under a lot of stress and was experiencing difficulty sleeping. Other findings included pale face, low voice, and tension on the trapezius muscle. The practitioner diagnosed this condition as qi and blood deficiencies, along with qi and blood stagnation. \u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e was prescribed, in which after one week of taking it, the patient had reported a dramatic improvement. Her ROM became 90% normal, and the other symptoms almost diminished. Submitted by N.V., Muir Beach, California.\u003c\/p\u003e\n\u003cp\u003e* A.B., a 22-year-old female, presented with anxiety and fear of failure. Additional symptoms she had been experiencing were depression, insomnia, and poor eating habits. It was noted that her \u003ci\u003eshen\u003c\/i\u003e (spirit) was not settled and she had dysglycemia. The practitioner diagnosed this condition as Liver qi stagnation and Spleen qi deficiency; Western diagnosis was low self-esteem along with low caloric diet. \u003cb\u003e\u003ci\u003eCalm (ES)\u003c\/i\u003e\u003c\/b\u003e was prescribed to take during the day and then \u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e to take at night. After two weeks she was then instructed to take \u003cb\u003e\u003ci\u003eSchisandra ZZZ\u003c\/i\u003e\u003c\/b\u003e at night and \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e during the day. \u003ci\u003eBu Zhong Yi Qi Tang\u003c\/i\u003e (Tonify the Middle and Augment the Qi Decoction) was taken as well until she began eating at regular intervals. After one month of taking the herbs, the insomnia had resolved and regular sleeping habits were occurring. In addition, her depression was lifted. She started experiencing major changes in attitude, life purpose and direction. Six weeks later she maintained her results by taking \u003cb\u003e\u003ci\u003eCalm\u003c\/i\u003e\u003c\/b\u003e. The anxiety had also reduced, only being anxious during stressful situations, which she had been resolving. She had also established regular eating habits, her energy had improved and her menses became regular without pain. Overall, the patient was very pleased with the outcome of taking the herbs. Submitted by N.T., Bethesda, Maryland.\u003c\/p\u003e\n\u003cp\u003e* S.C., a 62-year-old female, presented with pain in the right wrist due to practicing yoga, along with high stress and insomnia. The patient had not yet seen a Western doctor for this condition, but her TCM diagnosis was qi and blood stagnation in the Lung, Pericardium, and Heart channels. For treatment, \u003cb\u003e\u003ci\u003eArm Support\u003c\/i\u003e\u003c\/b\u003e and \u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e were prescribed at 3 to 4 capsules three times a day each. After taking the herbs for one week, the wrist pain had completely resolved and did not return. The additional symptoms of stress and sleep had improved during the course of the following two weeks. Afterwards, the patient no longer needed to take the \u003cb\u003e\u003ci\u003eArm Support\u003c\/i\u003e\u003c\/b\u003e and only continued taking the \u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e. Submitted by B.S., Niceville, Florida.\u003c\/p\u003e\n\u003cp\u003e* R.K., a 55-year-old female, presented with insomnia due to low back pain and stress. The practitioner diagnosed this condition as qi and blood stagnation in the Urinary Bladder channel and Liver qi stagnation. \u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e and \u003cb\u003e\u003ci\u003eBack Support (AC)\u003c\/i\u003e\u003c\/b\u003e were prescribed. After taking the herbs for two weeks, the back pain resolved temporarily. However, it still would come and go due to overuse. Over time, her sleep had improved as her back pain had gotten better. Submitted by B.S., Niceville, Florida.\u003c\/p\u003e\n\u003cp\u003e* J.F., a 38-year-old female, presented with sleep issues, difficulty falling asleep and staying asleep. Premenstrual irritability, mood swings, and anxiety during the day were also present. Other symptoms included palpitations and racing heart beat at night when working at 3:30 a.m. and 5:00 a.m. Blood pressure was 100\/62 mmHg and heart rate was 70 beats per minute. Objective findings were pale face, jitteriness and difficulty sitting still. The practitioner diagnosed this condition as Liver blood and yin deficiencies as well as Heart blood and yin deficiencies. The patient was given \u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e three capsules three times a day. \u003ci\u003eJia Wei Xiao Yao San\u003c\/i\u003e (Augmented Rambling Powder) was given at the onset of her PMS symptoms until day three of her period. With \u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e she was sleeping seven hours in a row consistently with some nights eight to ten hours as well as falling asleep after just 20 minutes vs. one to two hours before she took the herbs. The PMS symptoms also improved dramatically with much more even emotions. Submitted by L.M., Lafayette, Colorado.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003ePHARMACOLOGICAL AND CLINICAL RESEARCH\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e is an excellent formula to treat both the emotional and physical aspects of mental and psychological disorders. Pharmacological effects of this formula include anxiolytic effect to relieve stress and anxiety, antidepressant function to lift emotions, sedative and hypnotic benefits to treat insomnia, and muscle-relaxant action to relieve tension and stiffness. Clinical applications include stress, anxiety, depression and insomnia.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e has herbs with anxiolytic, antidepressant, and sedative effects to combat stress, anxiety, depression and insomnia. \u003ci\u003eSuan Zao Ren\u003c\/i\u003e (Semen Ziziphi Spinosae) has an anxiolytic effect to relieve stress and anxiety.[1] \u003ci\u003eZhi Mu\u003c\/i\u003e (Rhizoma Anemarrhenae) has demonstrated significant antidepressant activity on two experimental models of depression.[2] The proposed mechanism of the antidepressant activity of \u003ci\u003eZhi Mu\u003c\/i\u003e (Rhizoma Anemarrhenae) involves marked increase of noradrenaline and serotonin levels in both the hypothalamus and the hippocampus.[3] \u003ci\u003eChai Hu\u003c\/i\u003e (Radix Bupleuri), \u003ci\u003eGou Teng\u003c\/i\u003e (Ramulus Uncariae cum Uncis), \u003ci\u003eSuan Zao Ren\u003c\/i\u003e (Semen Ziziphi Spinosae) and \u003ci\u003eDa Zao\u003c\/i\u003e (Fructus Jujubae) have a calming effect on the brain to help the patients manage mental stress by promoting relaxation and improving sleeping.[4,5,6,7,8] Clinically, \u003ci\u003eSuan Zao Ren\u003c\/i\u003e (Semen Ziziphi Spinosae) has been used in many studies to successfully treat insomnia.[9,10]\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eGan Cao\u003c\/i\u003e (Radix et Rhizoma Glycyrrhizae), \u003ci\u003eXiao Mai\u003c\/i\u003e (Fructus Tritici) and \u003ci\u003eDa Zao\u003c\/i\u003e (Fructus Jujubae) are the three principle herbs in this formula. Together, these three herbs have been shown to have an excellent anxiolytic effect to treat disorders such as neurasthenia, hysteria, and insomnia. For neurasthenia, use of \u003ci\u003eGan Cao\u003c\/i\u003e (Radix et Rhizoma Glycyrrhizae), \u003ci\u003eXiao Mai\u003c\/i\u003e (Fructus Tritici), \u003ci\u003eDa Zao\u003c\/i\u003e (Fructus Jujubae) and others was shown to effectively treat 92 out of 100 patients.[11] For hysteria, concurrent use of acupuncture and these herbs effectively stabilized the condition and resolved the clinical signs and symptoms in all 60 patients, with no recurrence in follow-up visits 6 months after the conclusion of treatments.[12] For insomnia, use of \u003ci\u003eGan Cao\u003c\/i\u003e (Radix et Rhizoma Glycyrrhizae), \u003ci\u003eXiao Mai\u003c\/i\u003e (Fructus Tritici), \u003ci\u003eDa Zao\u003c\/i\u003e (Fructus Jujubae) and others was associated with a 74.2% overall rate of effectiveness in 110 patients.[13] Furthermore, concurrent use of \u003ci\u003eDa Zao\u003c\/i\u003e (Fructus Jujubae) and \u003ci\u003eGan Cao\u003c\/i\u003e (Radix et Rhizoma Glycyrrhizae) also has a positive cognitive effect to improve mental functions and ameliorate memory impairment.[14,15]\u003c\/p\u003e\n\u003cp\u003eIn addition, \u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e contains many herbs with analgesic, anti-inflammatory, and muscle-relaxant effects to help the body cope with muscle aches and pain due to stress. \u003ci\u003eBai Shao\u003c\/i\u003e (Radix Paeoniae Alba) and \u003ci\u003eGan Cao\u003c\/i\u003e (Radix et Rhizoma Glycyrrhizae) have anti-inflammatory and muscle-relaxant functions.[16,17] Clinically, these two herbs have marked effect to treat neck pain,[18] acute back pain,[19] sciatica,[20] pain in the lower back and legs,[21] leg cramps in the calf,[22] restless leg syndrome,[23] heel pain,[24] gastric and abdominal pain,[25] intestinal spasm,[26] menstrual cramps and pain,[27] neuralgia,[28] facial spasms and twitching,[29] trigeminal neuralgia,[30,31] and dysmenorrhea.[32] \u003ci\u003eXiang Fu\u003c\/i\u003e (Rhizoma Cyperi) illustrates its anti-inflammatory effect in dose- and time-dependent manners by inhibiting the production of nitric oxide and superoxide (O2-), two important mediators in the pathogenesis of inflammatory diseases.[33] \u003ci\u003eZhi Mu\u003c\/i\u003e (Rhizoma Anemarrhenae) exerts significant anti-inflammatory action by inhibiting cyclo-oxygenase-2, inducible nitric oxide synthase, and 5-lipoxygenase.[34] Lastly, \u003ci\u003eChai Hu\u003c\/i\u003e (Radix Bupleuri) demonstrates both analgesic and anti-inflammatory functions,[35,36] and the saikosaponins appear to be the main compounds for these actions.[37]\u003c\/p\u003e\n\u003cp\u003eLastly, to alleviate the adverse effects of stress on the digestive system, \u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e contains many herbs with gastroprotective effects. \u003ci\u003eGan Cao\u003c\/i\u003e (Radix et Rhizoma Glycyrrhizae) has a proven effect to prevent and treat peptic ulcers. The mechanisms of this action include inhibition of gastric acid secretion, binding and deactivation of gastric acid, and promotion of recovery from ulceration.[38] According to one study, 100 patients with gastric or duodenal ulcers were treated with \u003ci\u003eGan Cao\u003c\/i\u003e (Radix et Rhizoma Glycyrrhizae) with a 90% rate of effectiveness.[39] Another study also reported good results using \u003ci\u003eGan Cao\u003c\/i\u003e (Radix et Rhizoma Glycyrrhizae) to treat patients with peptic ulcers. The treatment protocol was to administer 2.5 to 5 grams of powdered \u003ci\u003eGan Cao\u003c\/i\u003e (Radix et Rhizoma Glycyrrhizae) three times daily for three to four weeks.[40]\u003c\/p\u003e\n\u003cp\u003eIn summary, \u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e is an excellent formula that treats both the emotional and physical aspects of mental and psychological disorders. Treatment of the emotional aspects of mental disorder includes use of herbs with anxiolytic effects to relieve stress and anxiety, and sedative and hypnotic effects to treat insomnia. Furthermore, treatment of the physical aspects of mental disorder includes use of herbs with muscle-relaxant effects to relieve tension and stiffness.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCOMPARATIVE ANALYSIS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eStress, anxiety, and insomnia are three conditions that often contribute to and aggravate each other. Clinical signs and symptoms include intrusive thoughts, illusions, hallucinations, difficulty concentrating, hypervigilance, restlessness, anger, irritability, and inability to fall and\/or stay asleep.\u003c\/p\u003e\n\u003cp\u003ePharmaceutical drug treatments for stress, anxiety, and insomnia focus primarily on use of benzodiazepines such as Valium (diazepam), Ativan (lorazepam), Halcion (triazolam), Restoril (temazepam), and Dalmane (flurazepam). Though these drugs are very potent and have an immediate effect to sedate patients, they do not address the underlying conditions. Furthermore, long-term use of these medications are associated with many side effects, including drowsiness, dizziness, tiredness, blurred vision, changes in sex drive or ability, shuffling walk, persistent, fine tremor or inability to sit still, difficulty breathing or swallowing, severe skin rash, yellowing of the skin or eyes, irregular heartbeat, and addiction. Therefore, these drugs should only be used when necessary, and only for a short period of time.\u003c\/p\u003e\n\u003cp\u003eUse of herbs is extremely effective to treat stress, anxiety, and insomnia. Herbs regulate mood and emotions, and alleviate stress and anxiety by enhancing the body's own ability to deal with these external factors. Furthermore, many herbs calm the \u003ci\u003eshen\u003c\/i\u003e (spirit) and help to restore normal sleeping patterns. Unlike benzodiazepine drugs that have immediate and potent sedative effects, herbs are moderate in potency, and may require one to two weeks to relieve stress, anxiety, and insomnia. In contrast, one of the main advantages of herbs is they are safe and natural, and do not have negative side effects like drugs.\u003c\/p\u003e\n\u003cp\u003eStress, anxiety, and insomnia are very common disorders. While drugs and herbs are both effective, they have contrasting differences of benefits and risks. While drugs are more effective for short-term treatment, herbs are more successful for long-term management. Furthermore, counseling (behavioral and psychotherapy) is extremely important toward the understanding of, and complete recovery from, these conditions.\u003c\/p\u003e\n\u003cp\u003e[1] Peng WH, Hsieh MT, Lee YS, Lin YC, Liao J. Anxiolytic effect of seed of Ziziphus jujuba in mouse models of anxiety. Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan, PR China. J Ethnopharmacol. 2000 Oct;72(3):435-41.\u003c\/p\u003e\n\u003cp\u003e[2] Ren LX, Luo YF, Li X, Wu YL. Antidepressant activity of sarsasapogenin from Anemarrhena asphodeloides Bunge (Liliaceae). School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China. Pharmazie. 2007 Jan;62(1):78-9.\u003c\/p\u003e\n\u003cp\u003e[3] Ren LX, Luo YF, Li X, Zuo DY, Wu YL. Antidepressant-like effects of sarsasapogenin from Anemarrhena asphodeloides BUNGE (Liliaceae). School of Pharmacy, Shenyang Pharmaceutical University, China. Biol Pharm Bull. 2006 Nov;29(11):2304-6.\u003c\/p\u003e\n\u003cp\u003e[4] Zhong Yao Yao Li Yu Ying Yong (Pharmacology and Applications of Chinese Herbs), 1983; 888.\u003c\/p\u003e\n\u003cp\u003e[5] Zhong Yao Yao Li Yu Ying Yong (Pharmacology and Applications of Chinese Herbs), 1983; 786.\u003c\/p\u003e\n\u003cp\u003e[6] Chang Yong Zhong Yao Xian Dai Yan Jiu Yu Lin Chuan (Recent Study \u0026amp; Clinical Application of Common Traditional Chinese Medicine), 1995; 489:491.\u003c\/p\u003e\n\u003cp\u003e[7] Cao JX, Zhang QY, Cui SY, Cui XY, Zhang J, Zhang YH, Bai YJ, Zhao YY. Hypnotic effect of jujubosides from Semen Ziziphi Spinosae. Department of Pharmacology, Peking University, School of Basic Medical Science, 38 Xueyuan Lu, Beijing 100191, China. J Ethnopharmacol. 2010 Jul 6;130(1):163-6.\u003c\/p\u003e\n\u003cp\u003e[8] Xian Dai Zhong Yao Yao Li Xue (Contemporary Pharmacology of Chinese Herbs), 1997; 1092.\u003c\/p\u003e\n\u003cp\u003e[9] Xin Zhong Yi (New Chinese Medicine), 1982; (11):35.\u003c\/p\u003e\n\u003cp\u003e[10] Shang Hai Zhong Yi Yao Za Zhi (Shanghai Journal of Chinese Medicine and Herbology), 1984; (10):30.\u003c\/p\u003e\n\u003cp\u003e[11] Jiang Su Yi Yao (Jiangsu Journal of Medicine and Herbology), 1976; 1:47.\u003c\/p\u003e\n\u003cp\u003e[12] Shan Dong Zhong Yi Za Zhi (Shandong Journal of Chinese Medicine), 1994; 5:237.\u003c\/p\u003e\n\u003cp\u003e[13] Zhe Jiang Zhong Yi Za Zhi (Zhejiang Journal of Chinese Medicine), 1982; 9:412.\u003c\/p\u003e\n\u003cp\u003e[14] Heo HJ, Park YJ, Suh YM, Choi SJ, Kim MJ, Cho HY, Chang YJ, Hong B, Kim HK, Kim E, Kim CJ, Kim BG, Shin DH. Effects of oleamide on choline acetyltransferase and cognitive activities. Biosci Biotechnol Biochem. 2003 Jun;67(6):1284-91.\u003c\/p\u003e\n\u003cp\u003e[15] Zhu Z, Li C, Wang X, Yang Z, Chen J, Hu L, Jiang H, Shen X. 2,2',4'-trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice. J Neurochem. 2010 Jul;114(2):374-85.\u003c\/p\u003e\n\u003cp\u003e[16] Zheng YQ, Wei W. Total glucosides of paeony suppresses adjuvant arthritis in rats and intervenes cytokine-signaling between different types of synoviocytes. Int Immunopharmacol. 2005 Sep;5(10):1560-73.\u003c\/p\u003e\n\u003cp\u003e[17] Leem K, Kim H, Boo Y, Lee HS, Kim JS, Yoo YC, Ahn HJ, Park HJ, Seo JC, Kim HK, Jin SY, Park HK, Chung JH, Cho JJ. Effects of Paeonia lactiflora root extracts on the secretions of monocyte chemotactic protein-1 and -3 in human nasal fibroblasts. Phytother Res. 2004 Mar;18(3):241-3.\u003c\/p\u003e\n\u003cp\u003e[18] Jiang Su Zhong Yi (Jiangsu Chinese Medicine), 1990; (10):29.\u003c\/p\u003e\n\u003cp\u003e[19] Zhe Jiang Zhong Yi Za Zhi (Zhejiang Journal of Chinese Medicine) 1995;(11):524.\u003c\/p\u003e\n\u003cp\u003e[20] Fu Jian Zhong Yi Yao (Fujian Chinese Medicine and Herbology), 1994; (1):7.\u003c\/p\u003e\n\u003cp\u003e[21] Yun Nan Zhong Yi (Yunnan Journal of Traditional Chinese Medicine), 1990; 4:15.\u003c\/p\u003e\n\u003cp\u003e[22] Zhong Yi Za Zhi (Journal of Chinese Medicine) 1985;6:450.\u003c\/p\u003e\n\u003cp\u003e[23] He Bei Zhong Yi (Hebei Chinese Medicine) 1984;3:29.\u003c\/p\u003e\n\u003cp\u003e[24] Si Chuan Zhong Yi (Sichuan Chinese Medicine) 1996;11:38.\u003c\/p\u003e\n\u003cp\u003e[25] Fu Jian Zhong Yi Yao (Fujian Chinese Medicine and Herbology) 1961;9(4):44.\u003c\/p\u003e\n\u003cp\u003e[26] Zhong Yi Za Zhi (Journal of Chinese Medicine), 1985; 6:50.\u003c\/p\u003e\n\u003cp\u003e[27] Bei Jing Zhong Yi (Beijing Chinese Medicine) 1983;(1):33.\u003c\/p\u003e\n\u003cp\u003e[28] Zhong Yi Ming Fang Lin Chuang Xin Yong (Contemporary Clinical Applications of Classic Chinese Formulas) 2001;313.\u003c\/p\u003e\n\u003cp\u003e[29] Zhong Xi Yi Jie He Za Zhi (Journal of Integrated Chinese and Western Medicine), 1991; (1):43.\u003c\/p\u003e\n\u003cp\u003e[30] Jiang Xi Yi Yao (Jiangxi Medicine and Herbology) 1965;5(7):909.\u003c\/p\u003e\n\u003cp\u003e[31] Zhong Yi Za Zhi (Journal of Chinese Medicine), 1983; 11:9.\u003c\/p\u003e\n\u003cp\u003e[32] Tanaka T. A novel anti-dysmenorrhea therapy with cyclic administration of two Japanese herbal medicines. Clinical \u0026amp; Experimental Obstetrics \u0026amp; Gynecology 2003;30(2-3):95-8.\u003c\/p\u003e\n\u003cp\u003e[33] Seo WG, et al. Inhibitory effects of methanol extract of Cyperus rotundus rhizomes on nitric oxide and superoxide productions by murine macrophage cell line, RAW 264.7 cells. Department of Microbiology, Wonkwang University School of Medicine, Iksan, 570-749, Chonbuk, South Korea. J Ethnopharmacol. 2001 Jun;76(1):59-64.\u003c\/p\u003e\n\u003cp\u003e[34] Lim H, Nam JW, Seo EK, Kim YS, Kim HP. (-)-Nyasol (cis-hinokiresinol), a norneolignan from the rhizomes of Anemarrhena asphodeloides, is a broad spectrum inhibitor of eicosanoid and nitric oxide production. College of Pharmacy, Kangwon National University, Chunchon 200-701, Korea. Arch Pharm Res. 2009 Nov;32(11):1509-14.\u003c\/p\u003e\n\u003cp\u003e[35] Shen Yang Yi Xue Yuan Xue Bao (Journal of Shenyang University of Medicine), 1984; 1(3):214.\u003c\/p\u003e\n\u003cp\u003e[36] Zhong Yao Yao Li Yu Ying Yong (Pharmacology and Applications of Chinese Herbs), 1983; 888.\u003c\/p\u003e\n\u003cp\u003e[37] Yamamoto M., Kumagai A. \u0026amp; Yamamura Y. () Structure and actions of saikosaponins isolated from Bupleurum falcatum L. I. Anti-inflammatory action of saikosaponins. Arzneim Forsch. 1975, 25: 1021-1023.\u003c\/p\u003e\n\u003cp\u003e[38] Zhong Yao Zhi (Chinese Herbology Journal), 1993; 358.\u003c\/p\u003e\n\u003cp\u003e[39] Zhong Hua Nei Ke Xue Za Zhi (Journal of Chinese Internal Medicine), 1960; 3:226.\u003c\/p\u003e\n\u003cp\u003e[40] Zhong Yao Lin Chuan Xin Yong (New Clinical Applications of Chinese Medicine), 2001; 163.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/div\u003e","brand":"Modern Herbal Formulas","offers":[{"title":"Default Title","offer_id":53171810992239,"sku":null,"price":50.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0726\/8630\/5391\/files\/CalmZZZ.jpg?v=1780094768"},{"product_id":"shine-depression-relief","title":"Shine = Depression relief","description":"\u003ch1\u003e\n\u003cb\u003eShine\u003c\/b\u003e \u003csup\u003e™\u003c\/sup\u003e\n\u003c\/h1\u003e\n\u003ch1\u003e\u003cb\u003eCLINICAL APPLICATIONS\u003c\/b\u003e\u003c\/h1\u003e\n\u003cp\u003e* \u003cb\u003eDepression\u003c\/b\u003e with low energy, prolonged sadness or irritability, and lack of interest in daily activities\u003c\/p\u003e\n\u003ch1\u003e\u003cb\u003eWESTERN THERAPEUTIC ACTIONS\u003c\/b\u003e\u003c\/h1\u003e\n\u003cp\u003e* Antidepressant effect to elevate mood and energy\u003c\/p\u003e\n\u003cp\u003e* Promotes the digestion and utilization of energy\u003c\/p\u003e\n\u003ch1\u003e\u003cb\u003eCHINESE THERAPEUTIC ACTIONS\u003c\/b\u003e\u003c\/h1\u003e\n\u003cp\u003e* Relieves food, qi, blood, and phlegm stagnation\u003c\/p\u003e\n\u003cp\u003e* Promotes movement of qi\u003c\/p\u003e\n\u003cp\u003e* Releases constraint\u003c\/p\u003e\n\u003ch1\u003e\u003cb\u003eDOSAGE\u003c\/b\u003e\u003c\/h1\u003e\n\u003cp\u003eTake 4 capsules three times daily with warm water on an empty stomach. Dosage may be increased up to 5 to 7 capsules if the condition is severe.\u003c\/p\u003e\n\u003ch1\u003e\u003cb\u003eINGREDIENTS\u003c\/b\u003e\u003c\/h1\u003e\n\u003cp\u003e\u003ci\u003eCha Ye\u003c\/i\u003e (Folium Camelliae)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eChai Hu\u003c\/i\u003e (Radix Bupleuri)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eChuan Xiong\u003c\/i\u003e (Rhizoma Chuanxiong)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eDa Zao\u003c\/i\u003e (Fructus Jujubae)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eGan Cao\u003c\/i\u003e (Radix et Rhizoma Glycyrrhizae)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eGuan Ye Jin Si Tao\u003c\/i\u003e (Herba Hyperici Perforati)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eHe Huan Pi\u003c\/i\u003e (Cortex Albiziae)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eLong Gu\u003c\/i\u003e (Os Draconis)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eMu Li\u003c\/i\u003e (Concha Ostreae)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eShen Qu\u003c\/i\u003e (Massa Fermentata)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eShi Chang Pu\u003c\/i\u003e (Rhizoma Acori Tatarinowii)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eXiang Fu\u003c\/i\u003e (Rhizoma Cyperi)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eYu Jin\u003c\/i\u003e (Radix Curcumae)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eYuan Zhi\u003c\/i\u003e (Radix Polygalae)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eZhi Zi\u003c\/i\u003e (Fructus Gardeniae)\u003c\/p\u003e\n\u003ch1\u003e\u003cb\u003eBACKGROUND\u003c\/b\u003e\u003c\/h1\u003e\n\u003cp\u003eDepression is a mood disorder characterized by severe or prolonged sadness that interferes with energy levels, daily functions and quality of life. Depression is characterized by symptoms such as fatigue, poor concentration, loss of interest and pleasure, and absence of sexual desires. While the exact cause of depression is unknown, common contributing factors include heredity, endocrine disorders, neurological disorders, mental disorders, and use of certain medications.\u003c\/p\u003e\n\u003ch1\u003e\u003cb\u003eFORMULA EXPLANATION\u003c\/b\u003e\u003c\/h1\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e is formulated specifically to treat depression, which according to traditional Chinese medicine is a disease caused by prolonged stagnation of qi, blood, dampness, and\/or food. The treatment protocol is to break up all stagnation and nourish the internal organs.\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eXiang Fu\u003c\/i\u003e (Rhizoma Cyperi) and \u003ci\u003eChai Hu\u003c\/i\u003e (Radix Bupleuri) promote the flow of Liver qi and reduce hypochondriac distension. \u003ci\u003eYu Jin\u003c\/i\u003e (Radix Curcumae) and \u003ci\u003eChuan Xiong\u003c\/i\u003e (Rhizoma Chuanxiong) relieve stagnation by invigorating blood flow. \u003ci\u003eShen Qu\u003c\/i\u003e (Massa Fermentata) helps digestion by removing food stagnation. \u003ci\u003eGan Cao\u003c\/i\u003e (Radix et Rhizoma Glycyrrhizae) and \u003ci\u003eDa Zao\u003c\/i\u003e (Fructus Jujubae) nourish the Heart and moisten internal dryness. \u003ci\u003eYuan Zhi\u003c\/i\u003e (Radix Polygalae) and \u003ci\u003eHe Huan Pi\u003c\/i\u003e (Cortex Albiziae) calm the \u003ci\u003eshen\u003c\/i\u003e (spirit) and relieve depression. \u003ci\u003eCha Ye\u003c\/i\u003e (Folium Camelliae) lifts the mood. \u003ci\u003eZhi Zi\u003c\/i\u003e (Fructus Gardeniae) sedates heat in the Heart and relieves irritability. \u003ci\u003eShi Chang Pu\u003c\/i\u003e (Rhizoma Acori Tatarinowii) opens the orifices, eliminates phlegm to increase alertness, and calms the \u003ci\u003eshen\u003c\/i\u003e (spirit). \u003ci\u003eLong Gu\u003c\/i\u003e (Os Draconis) and \u003ci\u003eMu Li\u003c\/i\u003e (Concha Ostreae) have tranquilizing functions to alleviate insomnia and dream-disturbed sleep. Finally, \u003ci\u003eGuan Ye Jin Si Tao\u003c\/i\u003e (Herba Hyperici Perforati), also known as St. John's Wort, is clinically found to be effective against depression, and enhances the overall effectiveness of this formula.\u003c\/p\u003e\n\u003cp\u003eIn short, \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e resolves food, qi, blood, and phlegm stagnation to lift depression.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCAUTIONS \u0026amp; CONTRAINDICATIONS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* This formula is contraindicated during pregnancy and nursing.\u003c\/p\u003e\n\u003cp\u003e* Use of \u003ci\u003eGuan Ye Jin Si Tao\u003c\/i\u003e (Herba Hyperici Perforati) is sometimes associated with increased photosensitivity. Patients should avoid excessive exposure to UV irradiation (e.g., sunlight, tanning) when using this herb.\u003c\/p\u003e\n\u003cp\u003e* Do not use \u003ci\u003eGuan Ye Jin Si Tao\u003c\/i\u003e (Herba Hyperici Perforati) while taking prescription drug(s) without advice of your prescribing physician. The following are two herb-drug interactions:\u003c\/p\u003e\n\u003cp\u003eThe concurrent use of \u003ci\u003eGuan Ye Jin Si Tao\u003c\/i\u003e (Herba Hyperici Perforati) and antidepressant drugs should be avoided, as the combination may lead to serotonin syndrome. The antidepressant drugs include monoamine oxidase inhibitors (MAOI), tricyclic antidepressants (TCA), and selective serotonin reuptake inhibitors (SSRI).[1]\u003c\/p\u003e\n\u003cp\u003eUse of \u003ci\u003eGuan Ye Jin Si Tao\u003c\/i\u003e (Herba Hyperici Perforati) may induce the cytochrome P450 system of the liver, leading to increased metabolism and decreased plasma concentration of certain drugs, such as Sandimmune\/Neoral (cyclosporine), combined oral contraceptive (ethinylestradiol and desogestrel), Theo-Dur (theophylline), Lanoxin (digoxin), and Crixivan (indinavir).[2]\u003c\/p\u003e\n\u003cp\u003e* Allergy warning: \u003ci\u003eShen Qu\u003c\/i\u003e (Massa Fermentata) used in this product contains wheat. Persons with allergy to wheat should not take this product.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCLINICAL NOTES\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* Depression may be treated effectively with \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e or \u003cb\u003e\u003ci\u003eShine (DS)\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e is more effective for depression characterized by stagnation (food, qi, blood and phlegm). \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e should not be used concurrently with antidepressant drugs, as this formula contains \u003ci\u003eGuan Ye Jin Si Tao\u003c\/i\u003e (Herba Hyperici Perforati), commonly known as St John's Wort.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eShine (DS)\u003c\/i\u003e\u003c\/b\u003e is more effective for depression with stress characterized by Liver qi stagnation and Heart fire. \u003cb\u003e\u003ci\u003eShine (DS)\u003c\/i\u003e\u003c\/b\u003e may be used concurrently with antidepressant drugs, as there are no known interactions.\u003c\/p\u003e\n\u003cp\u003e* Discontinuation of antidepressant drugs, particularly abruptly, may cause certain withdrawal symptoms. Therefore, it is best to taper off the drugs slowly, and offer herbal treatment simultaneously. \u003cb\u003e\u003ci\u003eShine (DS)\u003c\/i\u003e\u003c\/b\u003e may be used concurrently with antidepressant drugs or during the tapering process. \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e should not be used until the antidepressant drugs have been discontinued for two weeks.\u003c\/p\u003e\n\u003ch1\u003e\u003cb\u003eSUPPLEMENTARY FORMULAS\u003c\/b\u003e\u003c\/h1\u003e\n\u003cp\u003e* For vegetative depression with withdrawal, no desire to speak, poor appetite, and insomnia, combine with \u003cb\u003e\u003ci\u003eSchisandra ZZZ\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For depression with stress, anxiety, restlessness (manic-depressives), add \u003cb\u003e\u003ci\u003eCalm (ES)\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For chronic depressive patients who do not respond to any of the above treatment or show little result, add \u003cb\u003e\u003ci\u003eCirculation (SJ)\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For a quick boost of energy and vitality, combine with \u003cb\u003e\u003ci\u003eVibrant\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* Post-partum or for constant fatigue and lack of energy, combine with \u003cb\u003e\u003ci\u003eImperial Tonic\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* To strengthen the constitutional weakness and deficiency, use with \u003cb\u003e\u003ci\u003eCordyceps 3\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For loss of sexual desire, combine with \u003cb\u003e\u003ci\u003eVitality\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For over-weight or excessive weight gain, combine with \u003cb\u003e\u003ci\u003eHerbalite\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For patients who are burned out with adrenal insufficiency, use with \u003cb\u003e\u003ci\u003eAdrenal +\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For difficulty with concentration, poor memory or forgetfulness, use with \u003cb\u003e\u003ci\u003eEnhance Memory\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* With insomnia in patients who worry excessively or have anemia, \u003cb\u003e\u003ci\u003eSchisandra ZZZ\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For insomnia with stress in patients with deficiency, add \u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* Pre-menopausal and menopausal depression, add \u003cb\u003e\u003ci\u003eBalance (Heat)\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* With headache, add \u003cb\u003e\u003ci\u003eCorydalin (AC)\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For heat sensations, irritability or nightmares due to excess fire, add \u003cb\u003e\u003ci\u003eGardenia Complex\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003ch1\u003e\u003cb\u003eNUTRITION\u003c\/b\u003e\u003c\/h1\u003e\n\u003cp\u003e* Depression may be due in part to nutritional deficiency. Foods such as white bread, flour, saturated animal fats, hydrogenated vegetable oils, sweets, soft drinks, and canned goods deprive the body of B vitamins and increase the probability of depression.\u003c\/p\u003e\n\u003cp\u003e* Avoid a diet too low in complex carbohydrates as it may cause serotonin depletion and depression.\u003c\/p\u003e\n\u003ch1\u003e\u003cb\u003eGeneral Guidelines for a Healthy Diet\u003c\/b\u003e\u003c\/h1\u003e\n\u003cp\u003e* Eat a variety of fresh, organic fruits and vegetables of all colors.\u003c\/p\u003e\n\u003cp\u003e* Incorporate more high-fiber whole grains and nuts into diet.\u003c\/p\u003e\n\u003cp\u003e* Drink warm or hot liquids with meals.\u003c\/p\u003e\n\u003cp\u003e* Foods with antioxidant effects, such as vitamin A, C and E are beneficial. Beneficial foods include citrus fruits, carrots, green leaf vegetables, and green tea.\u003c\/p\u003e\n\u003cp\u003e* Chew food completely and thoroughly.\u003c\/p\u003e\n\u003cp\u003e* Always eat breakfast. According to the TCM clock, the most optimal time for the digestive system is in the morning from 8 to 10 a.m.\u003c\/p\u003e\n\u003cp\u003e* Give the body two to three hours between the last meal of the day and bedtime.\u003c\/p\u003e\n\u003cp\u003e* If the patient is allergic to any food or feel uncomfortable after eating certain foods, then avoid eating them.\u003c\/p\u003e\n\u003cp\u003e* Avoid fast food, processed foods, junk food, artificial sugars, and carbonated drinks.\u003c\/p\u003e\n\u003cp\u003e* The Spleen is responsible for generating post-natal qi. Foods that damage the Spleen should be avoided:\u003c\/p\u003e\n\u003cp\u003eAvoid any and all foods that contain sugar, such as cake, dessert, candy, chocolate, canned juice, soft drinks, caffeinated drinks, stevia, sugar substitutes, agave, xylitol, and corn syrup.\u003c\/p\u003e\n\u003cp\u003eAvoid raw or uncooked meats. Minimize consumption of foods that are cooling in nature, including tofu, tomato, celery, asparagus, bamboo, seaweed, kelp, bitter melon, cucumber, gourd, luffa, eggplant, winter melon, watermelon, honeydew, citrus, oranges, guava, grapefruit, pineapple, plums, pear, banana, papaya, white radish, mustard leaf, potherb mustard, Chinese kale, napa, and bamboo sprout. To make the property more neutral, one can add about 20 pieces of \u003ci\u003eGou Qi Zi\u003c\/i\u003e (Fructus Lycii) when cooking them.\u003c\/p\u003e\n\u003cp\u003e* Warm and hot natured foods that damage qi and yin should be avoided, such as certain fruits like mango and durian, stimulants like coffee, alcohol, and energy drinks, and spicy\/pungent\/aromatic vegetables such as pepper, garlic, onions, basil, rosemary, cumin, funnel, anise, leeks, chives, scallions, thyme, saffron, wormwood, mustard, chili pepper, and wasabi.\u003c\/p\u003e\n\u003cp\u003e* Avoid food and drinks with artificial coloring.\u003c\/p\u003e\n\u003cp\u003e* Consume as few meat products as possible. Do not eat processed meats, such as lunch meats, hot dogs and sausages, as they contain nitrites that are associated with inflammation and chronic disease.\u003c\/p\u003e\n\u003ch1\u003e\u003cb\u003eLIFESTYLE INSTRUCTIONS\u003c\/b\u003e\u003c\/h1\u003e\n\u003cp\u003e* Exercise outdoors and under the sun will help to lift depression.\u003c\/p\u003e\n\u003cp\u003e* A balanced lifestyle of work, rest and exercise is extremely important to achieve better mental and physical health.\u003c\/p\u003e\n\u003cp\u003e* Massaging the nerves along the spine will help to relieve tension associated with depression.\u003c\/p\u003e\n\u003ch1\u003e\u003cb\u003eCASE STUDIES\u003c\/b\u003e\u003c\/h1\u003e\n\u003cp\u003e* S.J., 31-year-old female, presented with depression. Symptoms included no social desire, lack of energy in the mornings, and easily fatigued. The practitioner diagnosed the condition as qi stagnation and Kidney qi deficiency. After taking \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e at three capsules three times a day, the patient felt immediate results of more energy and elevated mood. Submitted by L.M., Gresham, Oregon.\u003c\/p\u003e\n\u003cp\u003e* J.M., a 36-year-old female, presented with depression. She was a single mother with two children and a pending divorce. The diagnosis was qi and blood stagnation with Liver and Spleen disharmony. \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e was prescribed at 4 capsules three times daily. Results were apparent within 24 hours. Her depression began lifting the next day. Submitted by M.H., West Palm Beach, Florida.\u003c\/p\u003e\n\u003cp\u003e* W.P., a 45-year-old female, presented with pain in the kidney and liver areas with a history of Kidney infection and pancreatitis. She was also experiencing anxiety and depression. The practitioner diagnosed this condition as Liver qi stagnation with heat disturbing the \u003ci\u003eshen\u003c\/i\u003e (spirit). Upon diagnosis the patient was prescribed \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e and \u003cb\u003e\u003ci\u003eKidney DTX\u003c\/i\u003e\u003c\/b\u003e. Within four weeks the patient noticed her mood was stable. Submitted by T.W., Perrysburg, Ohio.\u003c\/p\u003e\n\u003cp\u003e* S.F., a 33-year-old female, presented with premenstrual symptoms consisting of fatigue and depression. The practitioner diagnosed this condition as qi deficiency with \u003ci\u003eshen\u003c\/i\u003e (spirit) disturbance. \u003cb\u003e\u003ci\u003eImperial Tonic\u003c\/i\u003e\u003c\/b\u003e, \u003cb\u003e\u003ci\u003eCalm\u003c\/i\u003e\u003c\/b\u003e and \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e were prescribed at 2 to 3 capsules each, three times a day. Submitted by S.L., Yuma, Arizona.\u003c\/p\u003e\n\u003cp\u003e* A.B., a 22-year-old female, presented with anxiety and fear of failure, depression, insomnia, and poor eating habits. The practitioner diagnosed this condition as Liver qi stagnation and Spleen qi deficiency. \u003cb\u003e\u003ci\u003eCalm (ES)\u003c\/i\u003e\u003c\/b\u003e was prescribed during the day and \u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e at night. After two weeks she was instructed to take \u003cb\u003e\u003ci\u003eSchisandra ZZZ\u003c\/i\u003e\u003c\/b\u003e at night and \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e during the day. After 1 month, the insomnia had resolved and her depression was lifted. Submitted by N.T., Bethesda, Maryland.\u003c\/p\u003e\n\u003cp\u003e* A 26-year-old female presented with chronic depression and was diagnosed with bipolar disorder. According to TCM, she was diagnosed with phlegm stagnation. Within a month of taking \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e, her somnolence subsided and she became more active. Submitted by T.G., Albuquerque, New Mexico.\u003c\/p\u003e\n\u003cp\u003e* A woman presented with depression and irritability, with a diagnosis of hepatitis C, fibromyalgia and Liver qi stagnation. After immediate administration of \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e, she began feeling much calmer. Submitted by M.H., Jupiter, Florida.\u003c\/p\u003e\n\u003cp\u003e* A 58-year-old male teacher presented with palpitations following the death of his significant other. The diagnosis was Liver oppressing the Heart and Liver yang rising. The patient was given 4 capsules of \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e three times daily for about six months. The patient displayed a 75% improvement within two weeks. Submitted by C.C., Cromwell, Connecticut.\u003c\/p\u003e\n\u003cp\u003e* A 42-year-old female finance administrator presented with plum-pit syndrome, belching, constipation, and irritability. The practitioner diagnosed the condition as Liver qi stagnation with dampness. The patient was instructed to take \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e. Significant improvements in the elimination of plum-pit qi and constipation were noted. Submitted by P.L., San Diego, California.\u003c\/p\u003e\n\u003cp\u003e* H.E., a 20-year-old female, presented with depression, difficulty with concentration, difficulty falling asleep, and short-temper. The diagnosis was Liver qi stagnation and Gallbladder\/Heart disharmony. \u003ci\u003eWen Dan Tang\u003c\/i\u003e (Warm the Gallbladder Decoction) and \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e were prescribed. Patient reported much improvement in symptoms. Submitted by S.F., Greenbrae, California.\u003c\/p\u003e\n\u003cp\u003e* A 53-year-old female patient presented with anxiety, depression and pale complexion. The TCM diagnosis was blood and yin deficiencies with Liver qi stagnation, Kidney yin and yang deficiencies. \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e and \u003cb\u003e\u003ci\u003eNourish\u003c\/i\u003e\u003c\/b\u003e, along with an iron supplement were prescribed. The patient noticed a change within the first ten days. Submitted by N.V., Muir Beach, California.\u003c\/p\u003e\n\u003cp\u003e* J.C., a 57-year-old female, presented with nervousness, insomnia, and anxiety with a desire to stop smoking. The practitioner diagnosed the condition as Kidney yin deficiency with heat and Liver qi stagnation. The patient was given a combination of \u003cb\u003e\u003ci\u003eNourish\u003c\/i\u003e\u003c\/b\u003e, \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e, and \u003cb\u003e\u003ci\u003eCalm\u003c\/i\u003e\u003c\/b\u003e. After six months, the patient reported improvement in sleep and was calmer overall. Submitted by K.F., Honolulu, Hawaii.\u003c\/p\u003e\n\u003cp\u003e* L.W., a 22-year-old male, presented with septic facial acne and depression. The TCM diagnosis was damp-heat with Liver qi stagnation. After one week of taking \u003cb\u003e\u003ci\u003eDermatrol (PS)\u003c\/i\u003e\u003c\/b\u003e and \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e, the acne was 80% resolved and the depression improving. The acne was gone in 28 days. Submitted by H.C., Stephens City, Virginia.\u003c\/p\u003e\n\u003ch1\u003e\u003cb\u003ePHARMACOLOGICAL AND CLINICAL RESEARCH\u003c\/b\u003e\u003c\/h1\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e is designed to treat depression by using herbs with demonstrated effectiveness to elevate mood, alleviate stress, and increase energy.\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eGuan Ye Jin Si Tao\u003c\/i\u003e (Herba Hyperici Perforati), commonly known as St. John's Wort, works primarily by increasing the level of serotonin and secondarily by inhibiting the enzyme monoamine oxidase (MAO).[3,4] Another study shows that hyperforin also has the effect of inhibiting the reuptake of serotonin and other neurotransmitters, such as norepinephrine and dopamine.[5] One study using the Hamilton Depression Scale found \u003ci\u003eGuan Ye Jin Si Tao\u003c\/i\u003e (Herba Hyperici Perforati) to be clinically effective in the treatment of depression with ratings close to a 70% treatment response.[6,7,8,9] In another study, the long-term intake of the herb for up to one year among 517 patients was deemed safe and effective, and especially suitable for relapse prevention.[10] According to a randomized, double-blind, comparative trial involving 149 outpatients, \u003ci\u003eGuan Ye Jin Si Tao\u003c\/i\u003e (Herba Hyperici Perforati) and Prozac (fluoxetine) demonstrated equivalent therapeutic effect for treatment of depression.[11] In another study with 1,757 patients, it was found to be significantly superior to placebo and similarly effective to antidepressant drugs.[12] Side effects are rare, with rash and photosensitivity being the most common.[14]\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eYuan Zhi\u003c\/i\u003e (Radix Polygalae) and \u003ci\u003eHe Huan Pi\u003c\/i\u003e (Cortex Albiziae) are two other herbs in \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e that have also shown marked effects to treat depression. Use of \u003ci\u003eYuan Zhi\u003c\/i\u003e (Radix Polygalae) is associated with marked antidepressant effects to reverse the harmful effects of chronic mild stress on mood and behaviors.[15] \u003ci\u003eHe Huan Pi\u003c\/i\u003e (Cortex Albiziae) exerts its antidepressant effect via the 5-HT1A receptor system, with therapeutic effect comparable to Tofranil (imipramine).[16] Clinically, one study reported 81.8% rate of effectiveness in treating depression in 33 patients using an herbal formula that contained \u003ci\u003eHe Huan Pi\u003c\/i\u003e (Cortex Albiziae) and \u003ci\u003eShi Chang Pu\u003c\/i\u003e (Rhizoma Acori Tatarinowii).[17]\u003c\/p\u003e\n\u003cp\u003eSince stress is a main contributor of depression, many herbs are used in this formula to calm the patient and alleviate depression, such as \u003ci\u003eChai Hu\u003c\/i\u003e (Radix Bupleuri),[18] \u003ci\u003eChuan Xiong\u003c\/i\u003e (Rhizoma Chuanxiong),[19] \u003ci\u003eDa Zao\u003c\/i\u003e (Fructus Jujubae),[20] and \u003ci\u003eXiang Fu\u003c\/i\u003e (Rhizoma Cyperi).[21] To improve sleep pattern and treat insomnia, \u003ci\u003eYuan Zhi\u003c\/i\u003e (Radix Polygalae) is added for its sedative effect.[22] To improve and increase energy, \u003ci\u003eShen Qu\u003c\/i\u003e (Massa Fermentata) is used to improve digestion and absorption of nutrients, and \u003ci\u003eCha Ye\u003c\/i\u003e (Folium Camelliae) is added to gently stimulate the central nervous system and increase body metabolism.[23,24,25]\u003c\/p\u003e\n\u003cp\u003eIn summary, \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e is a great formula to treat depression and its associated symptoms.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCOMPARATIVE ANALYSIS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eDepression is an emotional disorder that affects millions of people worldwide. The most commonly used drugs are the serotonin specific reuptake inhibitors (SSRI), such as Prozac (fluoxetine), Zoloft (sertraline), and Paxil (paroxetine). These drugs often require six to eight weeks before they exert their effect to lift depression, and are associated with a great number of side effects, including nausea, vomiting, weight loss, sexual dysfunction, and increased risk of suicide. Therefore, these drugs must be prescribed and monitored carefully.\u003c\/p\u003e\n\u003cp\u003e[1] Muller WE, Schafer C er al., In-vitro-Studie uber Hypericum-Extrakt, Hyericin und Kampferol. DAZ 136(13):1015-1022.1996.\u003c\/p\u003e\n\u003cp\u003e[2] PDR for Nutritional Supplements 1st Edition, Medical Economics, 2001.\u003c\/p\u003e\n\u003cp\u003e[3] Bombardelli, E. et al. Fitoterapia; 66(1):43-68. 1995.\u003c\/p\u003e\n\u003cp\u003e[4] Suzuki, O. et al. Planta Med; 2:272. 1984.\u003c\/p\u003e\n\u003cp\u003e[5] Muller, WE et al., Hyperforin represents the neurotransmitter reuptake inhibiting constituent of Hypericum extract. Pharmacopsychiatry 1998 Jun;31 Suppl 1:16-21.\u003c\/p\u003e\n\u003cp\u003e[6] Ernst, E. Fortschr Med; 113(25): 354-55. 1995.\u003c\/p\u003e\n\u003cp\u003e[7] Mueller, W. et al. Deutsche Apotheker Zeitung; 136:17-22,24. Mar 28, 1996.\u003c\/p\u003e\n\u003cp\u003e[8] DeSmet, P. et al. Br. Med J; 313:241-42. Aug 3, 1996.\u003c\/p\u003e\n\u003cp\u003e[9] Harrer, G. et al. Phytomedicine; 1:3-8. 1994.\u003c\/p\u003e\n\u003cp\u003e[10] Brattström A. Long-term effects of St. John's wort (Hypericum perforatum) treatment: a 1-year safety study in mild to moderate depression. Max Zeller Söhne Zeller AG, Seeblickstr. 4, CH-8590 Romanshorn, Switzerland. Phytomedicine. 2009 Apr;16(4):277-83.\u003c\/p\u003e\n\u003cp\u003e[11] Harrer, G et al., Comparison of equivalence between the St. John’s Wort extract LoHyp-57 and fluoxetine. Arzneimittelforschung 1999 Apr;(4):289-96.\u003c\/p\u003e\n\u003cp\u003e[12] Linde, K. et al. Br Med J; 313(7052):253-58. 1996.\u003c\/p\u003e\n\u003cp\u003e[13] Behnke K, Jensen GS, Graubaum HJ, Gruenwald J. Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression. PhytoPharm Consulting, Institute for Phytopharmaceuticals, Berlin, Germany. Adv Ther. 2002 Jan-Feb;19(1):43-52.\u003c\/p\u003e\n\u003cp\u003e[14] Muldner, VH. and Zoller, M. Arzneimittelforschung; 34:918. 1984.\u003c\/p\u003e\n\u003cp\u003e[15] Hu Y, Liu P, Guo DH, Rahman K, Wang DX, Xie TT. Antidepressant effects of the extract YZ-50 from Polygala tenuifolia in chronic mild stress treated rats and its possible mechanisms. Dept. of Clinical Pharmacology, Pharmacy Care Center, Chinese PLA General Hospital, Beijing 100853, China. Pharm Biol. 2010 Jul;48(7):794-800.\u003c\/p\u003e\n\u003cp\u003e[16] Kim JH, Kim SY, Lee SY, Jang CG. Antidepressant-like effects of Albizzia julibrissin in mice: involvement of the 5-HT1A receptor system. Department of Pharmacology, College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea. Pharmacol Biochem Behav. 2007 May;87(1):41-7.\u003c\/p\u003e\n\u003cp\u003e[17] Zhong Yao Lin Chuan Xin Yong (New Clinical Applications of Chinese Medicine), 2001; 282.\u003c\/p\u003e\n\u003cp\u003e[18] Zhong Yao Yao Li Yu Ying Yong (Pharmacology and Applications of Chinese Herbs), 1983; 888.\u003c\/p\u003e\n\u003cp\u003e[19] Zhong Yao Yao Li Yu Ying Yong (Pharmacology and Applications of Chinese Herbs), 1983:123.\u003c\/p\u003e\n\u003cp\u003e[20] Guo Wai Yi Xue Zhong Yi Zhong Yao Fen Ce (Monograph of Chinese Herbology from Foreign Medicine), 1985; 7(4):48.\u003c\/p\u003e\n\u003cp\u003e[21] Zhong Guo Yao Ke Da Xue Xue Bao (Journal of University of Chinese Herbology), 1989; 20(1):48.\u003c\/p\u003e\n\u003cp\u003e[22] Zhong Yao Yao Li Yu Ying Yong (Pharmacology and Applications of Chinese Herbs), 1983; 477.\u003c\/p\u003e\n\u003cp\u003e[23] Zhong Yao Xue (Chinese Herbology), 1998; 436:437.\u003c\/p\u003e\n\u003cp\u003e[24] Tyler, V. The New Honest Herbal. Philadelphia, PA: G.F. Stickley Co., 1987.\u003c\/p\u003e\n\u003cp\u003e[25] Olin, R. et al. The Lawrence Review of Natural Products by Facts and Comparison. Green Tea. May 1993.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eIn TCM, depression is characterized by stagnation of qi, blood, food, and phlegm. Therefore, optimal treatment requires use of herbs to relieve such stagnation. These same herbs have also been found to have an excellent effect to increase energy levels and lift depression. Generally speaking, most patients begin to benefit within approximately two weeks. Most importantly, these herbs are safe and natural, and are associated with few or no side effects.\u003c\/p\u003e\n\u003cp\u003eDepression is an emotional disorder that should be addressed cautiously. Though use of drugs is effective, one must carefully evaluate the potential benefits versus risks. In comparison, herbs are also effective, and definitely much safer. Furthermore, in addition to drug or herbal therapies, counseling and behavior therapy should be initiated as they are extremely helpful toward long-term improvement. Lastly, exercise is also helpful as this increases one's inherent ability to deal with stress and depression.\u003c\/p\u003e","brand":"Modern Herbal Formulas","offers":[{"title":"Default Title","offer_id":53171835994223,"sku":null,"price":28.33,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0726\/8630\/5391\/files\/Shine.jpg?v=1780095252"},{"product_id":"shine-ds-depression-and-stress","title":"Shine (DS) = Depression and stress","description":"\u003cp\u003e\u003cb\u003eShine (DS)\u003c\/b\u003e \u003csup\u003e™\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCLINICAL APPLICATIONS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* \u003cb\u003eDepression\/Stress\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* Anxiety, stress, irritability\u003c\/p\u003e\n\u003cp\u003e* Sadness, lack of interest\u003c\/p\u003e\n\u003cp\u003e* Possible chest distension, abdominal bloating, generalized weakness and\/or discomfort\u003c\/p\u003e\n\u003cp\u003e* \u003cb\u003eNote: This formula has no known interactions with antidepressant drugs.\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWESTERN THERAPEUTIC ACTIONS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* Antidepressant effect to elevate mood and lift depression\u003c\/p\u003e\n\u003cp\u003e* Anxiolytic effect to alleviate stress and anxiety\u003c\/p\u003e\n\u003cp\u003e* Gastrointestinal effect to regulate and restore normal digestive system and improve energy\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCHINESE THERAPEUTIC ACTIONS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* Spreads Liver qi\u003c\/p\u003e\n\u003cp\u003e* Clears Heart fire\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eDOSAGE\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eTake 3 to 4 capsules three times daily on an empty stomach. The dosage may be increased up to 6 to 8 capsules every four to six hours as needed.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eINGREDIENTS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eBai Shao\u003c\/i\u003e (Radix Paeoniae Alba)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eBai Zhu\u003c\/i\u003e (Rhizoma Atractylodis Macrocephalae)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eCang Zhu\u003c\/i\u003e (Rhizoma Atractylodis)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eChai Hu\u003c\/i\u003e (Radix Bupleuri)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eChuan Xiong\u003c\/i\u003e (Rhizoma Chuanxiong)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eDang Gui\u003c\/i\u003e (Radix Angelicae Sinensis)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eFu Ling\u003c\/i\u003e (Poria)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eHe Huan Pi\u003c\/i\u003e (Cortex Albiziae)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eMu Dan Pi\u003c\/i\u003e (Cortex Moutan)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eShen Qu\u003c\/i\u003e (Massa Fermentata)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eXiang Fu\u003c\/i\u003e (Rhizoma Cyperi)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eYuan Zhi\u003c\/i\u003e (Radix Polygalae)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eZhi Gan Cao\u003c\/i\u003e (Radix et Rhizoma Glycyrrhizae Praeparata cum Melle)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eZhi Mu\u003c\/i\u003e (Rhizoma Anemarrhenae)\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eZhi Zi\u003c\/i\u003e (Fructus Gardeniae)\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eBACKGROUND\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eDepression is a mood disorder that encompasses more than just sadness. Stress and anxiety are among the most common symptoms that also affect patients with depression, and more often than not, the symptoms from stress, anxiety, and depression are difficult to separate out.\u003c\/p\u003e\n\u003cp\u003eControlling depression with pharmaceuticals is difficult, and may require months of trial and error with different medications. Often a combination of two or more drugs is needed to keep depression under control. The disadvantages of using pharmaceuticals for the treatment of mood disorders include long-term dependency, and of course, the myriad side effects that may come with the medication, or the combination of medications. Traditional Chinese medicine (TCM) has a long history of dealing with mood disorders in an all-natural way. At the root of the issue is an imbalance of the internal organs; by correcting the relative imbalances of these organs, the individual's mood disorder should naturally improve. However, with TCM alone, it is often more difficult and time-consuming to treat serious mood disorders. Sometimes it is most effective to utilize a combination of Western and Chinese herbal medicine to gradually bring the patient back into health.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eFORMULA EXPLANATION\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eShine (DS)\u003c\/i\u003e\u003c\/b\u003e treats depression characterized by Liver qi stagnation accompanied by interior heat and underlying blood and Spleen deficiencies. Often, this constraint leads to other complications, such as stagnation of blood, phlegm, heat, dampness, and food. If the qi is stagnant in the chest and abdomen, qi is not able to ascend or descend freely; chest distension and oppression as well as abdominal fullness and pain may occur.\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eChai Hu\u003c\/i\u003e (Radix Bupleuri) and \u003ci\u003eXiang Fu\u003c\/i\u003e (Rhizoma Cyperi) enter the Liver channel to activate qi circulation and relieve qi stagnation. \u003ci\u003eMu Dan Pi\u003c\/i\u003e (Cortex Moutan), \u003ci\u003eZhi Mu\u003c\/i\u003e (Rhizoma Anemarrhenae) and \u003ci\u003eZhi Zi\u003c\/i\u003e (Fructus Gardeniae) sedate interior heat arising from Spleen and blood deficiencies, and from Liver qi stagnation. \u003ci\u003eChuan Xiong\u003c\/i\u003e (Rhizoma Chuanxiong) activates blood circulation to dispel blood stagnation. \u003ci\u003eBai Shao\u003c\/i\u003e (Radix Paeoniae Alba) and \u003ci\u003eDang Gui\u003c\/i\u003e (Radix Angelicae Sinensis) tonify the yin and the blood to contain the fire in the body.\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eBai Zhu\u003c\/i\u003e (Rhizoma Atractylodis Macrocephalae), \u003ci\u003eCang Zhu\u003c\/i\u003e (Rhizoma Atractylodis), and \u003ci\u003eFu Ling\u003c\/i\u003e (Poria) strengthen the Spleen and dry dampness to clear damp and phlegm stagnation. When the Spleen is strong, the patient is less likely to worry and overthink. \u003ci\u003eHe Huan Pi\u003c\/i\u003e (Cortex Albiziae) and \u003ci\u003eYuan Zhi\u003c\/i\u003e (Radix Polygalae) calm the \u003ci\u003eshen\u003c\/i\u003e (spirit). \u003ci\u003eShen Qu\u003c\/i\u003e (Massa Fermentata) promotes digestion, clears food stagnation and relieves the digestive symptoms arising from Liver overacting on the Spleen. Finally, \u003ci\u003eZhi Gan Cao\u003c\/i\u003e (Radix et Rhizoma Glycyrrhizae Praeparata cum Melle) harmonizes the entire formula.\u003c\/p\u003e\n\u003cp\u003eIn conclusion, \u003cb\u003e\u003ci\u003eShine (DS)\u003c\/i\u003e\u003c\/b\u003e treats depression and stress by regulating Liver qi and clearing interior heat.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCAUTIONS \u0026amp; CONTRAINDICATIONS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* This formula is contraindicated during pregnancy and nursing.\u003c\/p\u003e\n\u003cp\u003e* Allergy warning: \u003ci\u003eShen Qu\u003c\/i\u003e (Massa Fermentata) used in this product contains wheat. Persons with allergy to wheat should not take this product.\u003c\/p\u003e\n\u003cp\u003e* This herbal formula contains herbs that invigorate blood circulation, such as \u003ci\u003eDang Gui\u003c\/i\u003e (Radix Angelicae Sinensis). Therefore, patients who are on anticoagulant or antiplatelet therapies, such as Coumadin (warfarin), should use this formula with caution, or not at all, as there may be a higher risk of bleeding and bruising.[1,2,3]\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCLINICAL NOTES\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* Depression may be treated effectively with \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e or \u003cb\u003e\u003ci\u003eShine (DS)\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e is more effective for depression characterized by stagnation (food, qi, blood and phlegm). \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e should not be used concurrently with antidepressant drugs, as this formula contains \u003ci\u003eGuan Ye Jin Si Tao\u003c\/i\u003e (Herba Hyperici Perforati), commonly known as St John's Wort.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eShine (DS)\u003c\/i\u003e\u003c\/b\u003e is more effective for depression and stress characterized by Liver qi stagnation and Heart fire. \u003cb\u003e\u003ci\u003eShine (DS)\u003c\/i\u003e\u003c\/b\u003e may be used concurrently with antidepressant drugs, as there are no known interactions.\u003c\/p\u003e\n\u003cp\u003e* Discontinuation of antidepressant drugs, particularly abruptly, may cause certain withdrawal symptoms such as electric shock sensations (also known as brain shivers or brain zaps), dizziness, acute depression and irritability. Therefore, it is best to taper off the drugs slowly, and offer herbal treatment simultaneously. \u003cb\u003e\u003ci\u003eShine (DS)\u003c\/i\u003e\u003c\/b\u003e may be used concurrently with antidepressant drugs or during the tapering process. \u003cb\u003e\u003ci\u003eShine\u003c\/i\u003e\u003c\/b\u003e should not be used until the antidepressant drugs have been discontinued for two weeks.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eSUPPLEMENTARY FORMULAS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* With stress, anxiety, restlessness, and bipolar disorders (manic-depressives), add \u003cb\u003e\u003ci\u003eCalm (ES)\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For purplish tongue, blood stasis or chronic depression, add \u003cb\u003e\u003ci\u003eCirculation (SJ)\u003c\/i\u003e\u003c\/b\u003e in the first month of treatment.\u003c\/p\u003e\n\u003cp\u003e* With Liver blood deficiency and insomnia, add \u003cb\u003e\u003ci\u003eCalm ZZZ\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* With overthinking or over worrying due to Spleen qi deficiency, add \u003cb\u003e\u003ci\u003eSchisandra ZZZ\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* With indigestion and bloating, add \u003cb\u003e\u003ci\u003eGI Harmony\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For more phlegm, add \u003cb\u003e\u003ci\u003ePinellia Complex\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For constipation, add \u003cb\u003e\u003ci\u003eGentle Lax (Excess)\u003c\/i\u003e\u003c\/b\u003e or \u003cb\u003e\u003ci\u003eGentle Lax (Deficient)\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For a quick boost of energy and vitality, combine with \u003cb\u003e\u003ci\u003eVibrant\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For constant fatigue and lack of energy due to deficiency, combine with \u003cb\u003e\u003ci\u003eImperial Tonic\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For loss of sexual desire, combine with \u003cb\u003e\u003ci\u003eVitality\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For over-weight or obesity, combine with \u003cb\u003e\u003ci\u003eHerbalite\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For heat sensations, irritability or nightmares due to excess fire, add \u003cb\u003e\u003ci\u003eGardenia Complex\u003c\/i\u003e\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003e* For chronic depressive patients who do not respond to any of the above treatment or show little result, add \u003cb\u003e\u003ci\u003eCirculation (SJ)\u003c\/i\u003e\u003c\/b\u003e for two months and re-evaluate.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eNUTRITION\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* Depression may be due in part to nutritional deficiency. Foods such as white bread, flour, saturated animal fats, hydrogenated vegetable oils, sweets, soft drinks, and canned goods deprive the body of B vitamins and increase the probability of depression.\u003c\/p\u003e\n\u003cp\u003e* Avoid a diet too low in complex carbohydrates as it may cause serotonin depletion and depression.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eGeneral Guidelines for a Healthy Diet\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* Eat a variety of fresh, organic fruits and vegetables of all colors.\u003c\/p\u003e\n\u003cp\u003e* Incorporate more high-fiber whole grains and nuts into diet.\u003c\/p\u003e\n\u003cp\u003e* Drink warm or hot liquids with meals.\u003c\/p\u003e\n\u003cp\u003e* Foods with antioxidant effects, such as vitamin A, C and E are beneficial. Beneficial foods include citrus fruits, carrots, green leaf vegetables, and green tea.\u003c\/p\u003e\n\u003cp\u003e* Chew food completely and thoroughly.\u003c\/p\u003e\n\u003cp\u003e* Always eat breakfast. According to the TCM clock, the most optimal time for the digestive system is in the morning from 8 to 10 a.m.\u003c\/p\u003e\n\u003cp\u003e* Give the body two to three hours between the last meal of the day and bedtime.\u003c\/p\u003e\n\u003cp\u003e* If the patient is allergic to any food or feel uncomfortable after eating certain foods, then avoid eating it.\u003c\/p\u003e\n\u003cp\u003e* Avoid fast food, processed foods, junk food, artificial sugars, and carbonated drinks.\u003c\/p\u003e\n\u003cp\u003e* The Spleen is responsible for generating post-natal qi. Foods that damage the Spleen should be avoided:\u003c\/p\u003e\n\u003cp\u003eAvoid any and all foods that contain sugar, such as cake, dessert, candy, chocolate, canned juice, soft drinks, caffeinated drinks, stevia, sugar substitutes, agave, xylitol, and corn syrup.\u003c\/p\u003e\n\u003cp\u003eAvoid raw or uncooked meats. Minimize consumption of foods that are cooling in nature, including tofu, tomato, celery, asparagus, bamboo, seaweed, kelp, bitter melon, cucumber, gourd, luffa, eggplant, winter melon, watermelon, honeydew, citrus, oranges, guava, grapefruit, pineapple, plums, pear, banana, papaya, white radish, mustard leaf, potherb mustard, Chinese kale, napa, and bamboo sprout. To make the property more neutral, one can add about 20 pieces of \u003ci\u003eGou Qi Zi\u003c\/i\u003e (Fructus Lycii) when cooking them.\u003c\/p\u003e\n\u003cp\u003e* Warm and hot natured foods that damage qi and yin should be avoided, such as certain fruits like mango and durian, stimulants like coffee, alcohol, and energy drinks, and spicy\/pungent\/aromatic vegetables such as pepper, garlic, onions, basil, rosemary, cumin, funnel, anise, leeks, chives, scallions, thyme, saffron, wormwood, mustard, chili pepper, and wasabi.\u003c\/p\u003e\n\u003cp\u003e* Avoid food and drinks with artificial coloring.\u003c\/p\u003e\n\u003cp\u003e* Consume as few meat products as possible. Do not eat processed meats, such as lunch meats, hot dogs and sausages, as they contain nitrites that are associated with inflammation and chronic disease.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eLIFESTYLE INSTRUCTIONS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e* Regular use of steam rooms or saunas can help to eliminate toxins through sweating.\u003c\/p\u003e\n\u003cp\u003e* Take a 30-minute walk after meals to help stimulate the circulatory and digestive systems.\u003c\/p\u003e\n\u003cp\u003e* Incorporate some form of cardiovascular exercise.\u003c\/p\u003e\n\u003cp\u003e* Do not postpone bowel movements, respond to the urge immediately.\u003c\/p\u003e\n\u003cp\u003e* Sleep by 10:00 p.m. In traditional Chinese medicine (TCM), 11:00 p.m. to 1:00 a.m. is when the yin shifts to yang. It is crucial for the body to be at rest during this time for optimal health.\u003c\/p\u003e\n\u003cp\u003e* Eliminate things that are unhealthy (e.g., alcohol, coffee, cigarettes, refined sugars, or saturated fats) or potentially toxic (e.g. chemical-based household cleaners and personal hygiene products).\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eMODERN RESEARCH\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eShine (DS)\u003c\/i\u003e\u003c\/b\u003e is designed to treat depression by using herbs with demonstrated effectiveness to elevate mood, alleviate stress, and reduce anxiety.\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eZhi Mu\u003c\/i\u003e (Rhizoma Anemarrhenae), \u003ci\u003eYuan Zhi\u003c\/i\u003e (Radix Polygalae), and \u003ci\u003eHe Huan Pi\u003c\/i\u003e (Cortex Albiziae) are three herbs in this formula that have shown marked effects to treat depression. \u003ci\u003eZhi Mu\u003c\/i\u003e (Rhizoma Anemarrhenae) contains sarsasapogenin which has shown significant antidepressant activity on two experimental models of depression.[4] \u003ci\u003eZhi Mu\u003c\/i\u003e (Rhizoma Anemarrhenae) exerts its antidepressant influences in both the hypothalamus and the hippocampus.[5] Use of \u003ci\u003eYuan Zhi\u003c\/i\u003e (Radix Polygalae) is associated with a marked antidepressant effect to reverse the harmful effects of chronic mild stress on mood and behavior.[6] Lastly, \u003ci\u003eHe Huan Pi\u003c\/i\u003e (Cortex Albiziae) exhibits comparable antidepressant effect to Tofranil (imipramine), a tricyclic antidepressant drug.[7] Clinically, one study reported an 81.8% rate of effectiveness in treating depression in 33 patients using an herbal formula that contained \u003ci\u003eHe Huan Pi\u003c\/i\u003e (Cortex Albiziae), \u003ci\u003eShi Chang Pu\u003c\/i\u003e (Rhizoma Acori Tatarinowii), and others.[8]\u003c\/p\u003e\n\u003cp\u003eBeyond using herbs to directly treat depression, \u003cb\u003e\u003ci\u003eShine (DS)\u003c\/i\u003e\u003c\/b\u003e incorporates other herbs to support the patient and treat other aspects of depression. Since stress is a main contributor of depression, many herbs are used in this formula to calm the patient and alleviate depression, such as \u003ci\u003eChai Hu\u003c\/i\u003e (Radix Bupleuri),[9] \u003ci\u003eChuan Xiong\u003c\/i\u003e (Rhizoma Chuanxiong),[10] and \u003ci\u003eXiang Fu\u003c\/i\u003e (Rhizoma Cyperi).[11] To improve sleep pattern and treat insomnia, \u003ci\u003eYuan Zhi\u003c\/i\u003e (Radix Polygalae) is added for its sedative effect.[12] To improve and increase energy, \u003ci\u003eShen Qu\u003c\/i\u003e (Massa Fermentata) is used to improve digestion and absorption of nutrients,[13] \u003ci\u003eBai Zhu\u003c\/i\u003e (Rhizoma Atractylodis Macrocephalae) and \u003ci\u003eCang Zhu\u003c\/i\u003e (Rhizoma Atractylodis) are incorporated to regulate and restore the digestive system,[14,15] and \u003ci\u003eZhi Gan Cao\u003c\/i\u003e (Radix et Rhizoma Glycyrrhizae Praeparata cum Melle) is utilized to protect and repair the intestines.[16] Lastly, \u003ci\u003eBai Zhu\u003c\/i\u003e (Rhizoma Atractylodis Macrocephalae) has an adaptogenic effect to facilitate adjustment to various mental and physical stress.[17]\u003c\/p\u003e\n\u003cp\u003eIn summary, \u003cb\u003e\u003ci\u003eShine (DS)\u003c\/i\u003e\u003c\/b\u003e is a great formula to treat depression and its associated symptoms.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCOMPARATIVE ANALYSIS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eDepression is an emotional disorder that affects millions of people worldwide. In Western medicine, the biomedical understanding of depression is relatively new, as antidepressant drugs were mostly developed only in the last two decades. Though there are several categories of drugs for depression, the most commonly used are the serotonin specific reuptake inhibitors (SSRI), such as Prozac (fluoxetine), Zoloft (sertraline), and Paxil (paroxetine). These drugs often require six to eight weeks before they exert their effect to lift depression, and are associated with a great number of side effects, including nausea, vomiting, weight loss, sexual dysfunction, and increased risk of suicide. Therefore, these drugs must be prescribed and monitored carefully to avoid such adverse reactions.\u003c\/p\u003e\n\u003cp\u003eIn TCM, depression is characterized by stagnation of qi, blood, food, and phlegm. If untreated or poorly treated, these stagnations can create heat, causing Heart fire and \u003ci\u003eshen\u003c\/i\u003e (spirit) disturbance. Therefore, optimal treatment requires use of herbs to relieve stagnation and clear Heart fire. These same herbs have also been found to have an excellent effect to increase energy levels and lift depression. Generally speaking, most patients begin to benefit within approximately two weeks. Most importantly, these herbs are safe and natural, and are associated with few or no side effects.\u003c\/p\u003e\n\u003cp\u003eDepression is an emotional disorder that should be addressed cautiously. Though use of drugs is effective, one must carefully evaluate the potential benefits against the potential risks. Once the decision is made to start drug therapy, the patient must be monitored carefully to ensure that the drugs do not cause serious side effects. In comparison, herbs are also effective, and definitely much safer. It provides an additional option that should be explored. Furthermore, in addition to drug or herbal therapies, counseling and behavior therapy should be initiated as they are extremely helpful toward long-term improvement. Lastly, exercise is also helpful as it increases one's inherent ability to deal with stress and depression.\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cdiv id=\"h1\"\u003e\n\u003cdiv\u003e\n\u003cdiv id=\"edn1\"\u003e\n\u003cp class=\"MsoEndnoteText\"\u003e\u003cspan class=\"MsoEndnoteReference\"\u003e\u003cspan\u003e[1]\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e Chan K, Lo AC, Yeung JH, Woo KS. Journal of Pharmacy and Pharmacology 1995 May;47(5):402-6.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"edn2\"\u003e\n\u003cp class=\"MsoEndnoteText\"\u003e\u003cspan class=\"MsoEndnoteReference\"\u003e\u003cspan\u003e[2]\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e Pharmacotherapy 1999 July;19(7):870-876.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"edn3\"\u003e\n\u003cp class=\"MsoEndnoteText\"\u003e\u003cspan class=\"MsoEndnoteReference\"\u003e\u003cspan\u003e[3]\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e European Journal of Drug Metabolism and Pharmacokinetics 1995; 20(1):55-60.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"edn4\"\u003e\n\u003cp class=\"MsoEndnoteText\"\u003e\u003cspan class=\"MsoEndnoteReference\"\u003e\u003cspan\u003e[4]\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e Ren LX, Luo YF, Li X, Wu YL. Antidepressant activity of sarsasapogenin from Anemarrhena asphodeloides Bunge (Liliaceae). School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China. Pharmazie. 2007 Jan;62(1):78-9.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"edn5\"\u003e\n\u003cp class=\"MsoEndnoteText\"\u003e\u003cspan class=\"MsoEndnoteReference\"\u003e\u003cspan\u003e[5]\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e Ren LX, Luo YF, Li X, Zuo DY, Wu YL. Antidepressant-like effects of sarsasapogenin from Anemarrhena asphodeloides BUNGE (Liliaceae). School of Pharmacy, Shenyang Pharmaceutical University, China. Biol Pharm Bull. 2006 Nov;29(11):2304-6.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"edn6\"\u003e\n\u003cp class=\"MsoEndnoteText\"\u003e\u003cspan class=\"MsoEndnoteReference\"\u003e\u003cspan\u003e[6]\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e Hu Y, Liu P, Guo DH, Rahman K, Wang DX, Xie TT. Antidepressant effects of the extract YZ-50 from Polygala tenuifolia in chronic mild stress treated rats and its possible mechanisms. Dept. of Clinical Pharmacology, Pharmacy Care Center, Chinese PLA General Hospital, Beijing 100853, China. Pharm Biol. 2010 Jul;48(7):794-800.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"edn7\"\u003e\n\u003cp class=\"MsoEndnoteText\"\u003e\u003cspan class=\"MsoEndnoteReference\"\u003e\u003cspan\u003e[7]\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e Kim JH, Kim SY, Lee SY, Jang CG. Antidepressant-like effects of Albizzia julibrissin in mice: involvement of the 5-HT1A receptor system. Department of Pharmacology, College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea. Pharmacol Biochem Behav. 2007 May;87(1):41-7.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"edn8\"\u003e\n\u003cp class=\"MsoEndnoteText\"\u003e\u003cspan class=\"MsoEndnoteReference\"\u003e\u003cspan\u003e[8]\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e \u003ci\u003eZhong Yao Lin Chuan Xin Yong\u003c\/i\u003e (New Clinical Applications of Chinese Medicine), 2001; 282.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"edn9\"\u003e\n\u003cp class=\"MsoEndnoteText\"\u003e\u003cspan class=\"MsoEndnoteReference\"\u003e\u003cspan\u003e[9]\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e \u003ci\u003eZhong Yao Yao Li Yu Ying Yong \u003c\/i\u003e(Pharmacology and Applications of Chinese Herbs), 1983; 888.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"edn10\"\u003e\n\u003cp class=\"MsoEndnoteText\"\u003e\u003cspan class=\"MsoEndnoteReference\"\u003e\u003cspan\u003e[10]\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e \u003ci\u003eZhong Yao Yao Li Yu Ying Yong \u003c\/i\u003e(Pharmacology and Applications of Chinese Herbs), 1983:123.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"edn11\"\u003e\n\u003cp class=\"MsoEndnoteText\"\u003e\u003cspan class=\"MsoEndnoteReference\"\u003e\u003cspan\u003e[11]\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e \u003ci\u003eZhong Guo Yao Ke Da Xue Xue Bao \u003c\/i\u003e(Journal of University of Chinese Herbology), 1989; 20(1):48.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"edn12\"\u003e\n\u003cp class=\"MsoEndnoteText\"\u003e\u003cspan class=\"MsoEndnoteReference\"\u003e\u003cspan\u003e[12]\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e \u003ci\u003eZhong Yao Yao Li Yu Ying Yong \u003c\/i\u003e(Pharmacology and Applications of Chinese Herbs), 1983; 477.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"edn13\"\u003e\n\u003cp class=\"MsoEndnoteText\"\u003e\u003cspan class=\"MsoEndnoteReference\"\u003e\u003cspan\u003e[13]\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e \u003ci\u003eZhong Yao Xue \u003c\/i\u003e(Chinese Herbology), 1998; 436:437.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"edn14\"\u003e\n\u003cp class=\"MsoEndnoteText\"\u003e\u003cspan class=\"MsoEndnoteReference\"\u003e\u003cspan\u003e[14]\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e \u003ci\u003eChang Yong Zhong Yao Cheng Fen Yu Yao Li Shou Ce \u003c\/i\u003e(A Handbook of the Composition and Pharmacology of Common Chinese Drugs), 1994; 739:742.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"edn15\"\u003e\n\u003cp class=\"MsoEndnoteText\"\u003e\u003cspan class=\"MsoEndnoteReference\"\u003e\u003cspan\u003e[15]\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e Kimura Y, Sumiyoshi M. Effects of an Atractylodes lancea rhizome extract and a volatile component β-eudesmol on gastrointestinal motility in mice. J Ethnopharmacol. 2012 May 7;141(1):530-6.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"edn16\"\u003e\n\u003cp class=\"MsoEndnoteText\"\u003e\u003cspan class=\"MsoEndnoteReference\"\u003e\u003cspan\u003e[16]\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e He Y, Zhang X, Zeng X, Huang Y, Wei JA, Han L, Li CX, Zhang GW. HuR-mediated posttranscriptional regulation of p21 is involved in the effect of Glycyrrhiza uralensis licorice aqueous extract on polyamine-depleted intestinal crypt cells proliferation. J Nutr Biochem. 2012 Jan 2.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"edn17\"\u003e\n\u003cp class=\"MsoEndnoteText\"\u003e\u003cspan class=\"MsoEndnoteReference\"\u003e\u003cspan\u003e[17]\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e \u003ci\u003eXin Yi Yao Xue Za Zhi \u003c\/i\u003e(New Journal of Medicine and Herbology), 1974; 8:13.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd width=\"10%\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Modern Herbal Formulas","offers":[{"title":"Default Title","offer_id":53171856244847,"sku":null,"price":28.33,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0726\/8630\/5391\/files\/ShineDS.jpg?v=1780095526"}],"url":"https:\/\/modernherbalformulas.com\/collections\/stress-and-sleep.oembed","provider":"Modern Herbal Formulas","version":"1.0","type":"link"}